Application Note: Robust and reproducible characterization of mAb and ADC charge variants
25 March 2020

In this application note, Waters perform strong cation exchange ultra-performance liquid chromatography coupled to UV with a non-volatile salt/pH gradient as well as LC-UV-MS using volatile MS-compatible salts. In-depth analyses were performed on AJICAP mAb and ADC charge variants to allow for effective resolution and characterization of charge variants throughout the ADC manufacturing process.

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