Scientific Poster: Robust and reproducible characterization of mAb and ADC charge variants
25 March 2020
In this application note, Waters perform strong cation exchange ultra-performance liquid chromatography coupled to UV with a non-volatile salt/pH gradient as well as LC-UV-MS using volatile MS-compatible salts. In-depth analyses were performed on AJICAP mAb and ADC charge variants to allow for effective resolution and characterization of charge variants throughout the ADC manufacturing process.