Application Note: Online IEX-MS characterization and monitoring of mAb charge heterogeneity
25 March 2020

Ion exchange chromatography (IEX) is a method of choice for the analysis of charge heterogeneity encountered with biotherapeutic drug candidates. In this study, Waters conducted MS-compatible IEX separations combined with a new small footprint benchtop time-of-flight (TOF) MS instrument and applied to a case study on identifying the charge variants formed upon forced degradation.