Application Note: LC-MS/MS Detection of Fentanyl and Related Synthetic Opioids in Biological Matrices
3 February 2019

The potency of these compounds result in small concentrations being detected in real-world samples, thus requiring methods utilized by a forensic or clinical laboratory to be very sensitive. Hyphenated techniques such liquid chromatography-tandem mass spectrometry (LC-MS/MS) can achieve this needed sensitivity through multiple reaction monitoring (MRM). The Shimadzu LCMS-8060 features a heated dual ionization source (DUIS) coupled with a along with ultrafast MRM acquisition software and polarity switching for increased accuracy, sensitivity and robustness.