Application Note: Intact Mass Analysis of Monoclonal Antibody (MAb) Charge Variants Separated Using Linear pH Gradient
2 February 2015

This application note demonstrates intact mass analysis of monoclonal antibody (MAb) charge variants being separated using linear pH gradient method on a cation-exchange column. The intact mass information is acquired on the Thermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap mass spectrometer.