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High Mass Resolution is Essential for Confident Compound Detection

High Mass Resolution is Essential for Confident Compound Detection

17 Nov 2015

Analytical laboratories are under ever-increasing pressure to deliver fast results, while maintaining the highest levels of accuracy and confidence. The majority of these laboratories rely on targeted analytical approaches, using both gas chromatography and liquid chromatography coupled to triple quadrupole mass spectrometry (MS) instrumentation. These techniques cover the wide range of chemical classes to be monitored at the required levels of sensitivity and selectivity. However, they are limited to those compounds in the target list and they require careful optimization of acquisition parameters for each compound. This application note explains how high resolution, full scan mass spectrometry provides a solution to the demand for detection and quantification of a growing number of compounds and the retrospective analysis of samples long after data acquisition.

Thermo Scientific™ Q Exactive™ GC Orbitrap™ GC-MS/MS System

Thermo Fisher Scientific

The Thermo Scientific™ Q Exactive™ GC system is the first-ever combination of high resolution gas chromatography with high-resolution/accurate-mass (HR/AM) Orbitrap detection for the most comprehensive sample characterization. This easy-to-use system provides the most comprehensive characterization of samples in a single analysis for the highest confidence in compound discovery, identification, and quantitation. Building upon the flexible modularity of the Thermo Scientific™ TRACE™ 1300 Series GC, including user-exchangeable injectors and detectors, the Q Exactive GC system has the quantitative power of a GC triple quadrupole MS combined with the high precision, full scan high-resolution/accurate-mass capability that only Orbitrap technology can offer.   Key Features: Advanced quadrupole technology (AQT) for high transmission of selected masses Resolving power up to 120,000 at m/z 200 Part-per-trillion-level sensitivity Thermo Scientific™ Extractabrite™ ion source for robust, rugged electron impact (EI) and chemical ionization (CI) performance Curved linear C-trap for precise ion injection HCD collision cell for higher energy collisional dissociation provides MS/MS ion characterization Intelligent identification software elucidates the nature of each injected sample. Applications: Untargeted and targeted metabolomics Food and beverage Industrial analyses Environmental Pharmaceutical Clinical and toxicology

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High Mass Resolution is Essential for Confident Compound Detection