Cultivation of PER.C6R Cells in the Single Use Bioreactor BIOSTATR CultiBag RM for the Production of Monoclonal anti-EpCAM Antibodies
4 May 2011In this application note, Sartorius report the successful cultivation of PER.C6R in the single-use bioreactor BIOSTATR CultiBag RM. Chemically defined, serum-free media is used for the purpose of producing a high titer of monoclonal antibody in batch and simple fed-batch regime. The growth of the PER.C6R cells in the CultiBag RM was compared to growth in single use shaker flasks.
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BIOSTAT® CultiBag RM single use bioreactor
Sartorius GroupBIOSTAT® CultiBag RM single-use bioreactor for the cultivation of all cell types, including mammalian cells, plant cells, insect cells, stem cells and microbial cells. Application-driven packages are available for culturing from 100 ml to 300 l. BIOSTAT® CultiBag RM is a single-use bioreactor utilising rocking motion agitation with low shear. The feedback control loops using single use sensors for pH and DO, bring new levels of confidence to process development.