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Benefits of Using ACQUITY QDa Mass Detection for Quantitative Analysis of Non-Chromophoric Memantine HCl in Tablet Formulation

26 Jan 2016

In this application note, we describe the use of the ACQUITY QDa module, a small but robust, simple-to-use mass detector, to quantitate non-chromophoric memantine HCl, a drug commonly used to treat dementia often associated with Alzheimer’s disease. Here, we present a UPLC method coupled with the ACQUITY QDa Detector to quantitatively determine memantine HCl in the drug tablet formulation. We will demonstrate the system suitability, method linearity, and specificity achievable with mass detection for routine assays.

ACQUITY QDa Mass Detector

Waters

The ACQUITY QDa® Mass Detector gives you certainty above all else. You can minimize the risk of unexpected coelutions or components and confirms trace components with the analytical confidence of mass detection. The ACQUITY QDa® Detector is a mass detector built around the needs of analytical scientists for chromatographic analysis. Robust, reliable and requiring no sample adjustments, it just integrates with your current LC, ACQUITY UPLC, ACQUITY UPC2 and purification systems. You'll enhance the analytical value and productivity of each analysis, and you won't need to run all the additional assays or time-consuming alternative techniques or even wait for results from specialist labs that cost your laboratory productivity. With the ACQUITY QDa® Detector, you now have information-rich mass spectral data to complement data from your current Waters® optical detectors, including the ACQUITY UPLC PDA, TUV, ELS, and FLR detectors, as well as the ACQUITY UPC² PDA Detector. This mass spectral information integrates seamlessly into the same workflow; routinely giving you more complete separation characterization. Features: Intuitive operation More information from every sample Effortless integration Increased efficiency Resolving complexity Applications: Food & Environment Life Sciences and Pharmaceuticals Chemical

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Benefits of Using ACQUITY QDa Mass Detection for Quantitative Analysis of Non-Chromophoric Memantine HCl in Tablet Formulation