Applying Improved TOF Mass Resolving Capability to Enhance the Characterization of Therapeutic Antibodies in Middle-Up and –Down Workflows
Applying Improved TOF Mass Resolving Capability to Enhance the Characterization of Therapeutic Antibodies in Middle-Up and –Down Workflows
15 Jun 2015This poster demonstrates a method to extend the specificity of intact mass analysis and Middle-Down sequencing by deploying MD MALDI-ISD for high quality identification of sequence variations in combination with a new ultrahigh resolution (UHR)-ESI QTOF providing monoisotopic mass determinations of HCs with no speed or dynamic range compromise.
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