Adding Cost Effective Mass Detection as an Orthogonal Technique for Improved Productivity and Confidence in the Analysis of Protein Biotherapeutics

Adding Cost Effective Mass Detection as an Orthogonal Technique for Improved Productivity and Confidence in the Analysis of Protein Biotherapeutics

1 Jul 2015

This poster presents an analytical strategy for the acquisition of optical and MS based data necessary for the efficient monitoring of critical quality attributes (CQAs) associated with a mAb in a single cost-effective workflow. While optical detection provide some assurance, the use of an orthogonal detection technique like mass detection expands detection limits, improves specificity and increases confidence in peak homogeneity.

ACQUITY QDa Mass Detector

Waters

The ACQUITY QDa® Mass Detector gives you certainty above all else. You can minimize the risk of unexpected coelutions or components and confirms trace components with the analytical confidence of mass detection. The ACQUITY QDa® Detector is a mass detector built around the needs of analytical scientists for chromatographic analysis. Robust, reliable and requiring no sample adjustments, it just integrates with your current LC, ACQUITY UPLC, ACQUITY UPC2 and purification systems. You'll enhance the analytical value and productivity of each analysis, and you won't need to run all the additional assays or time-consuming alternative techniques or even wait for results from specialist labs that cost your laboratory productivity. With the ACQUITY QDa® Detector, you now have information-rich mass spectral data to complement data from your current Waters® optical detectors, including the ACQUITY UPLC PDA, TUV, ELS, and FLR detectors, as well as the ACQUITY UPC² PDA Detector. This mass spectral information integrates seamlessly into the same workflow; routinely giving you more complete separation characterization. Features: Intuitive operation More information from every sample Effortless integration Increased efficiency Resolving complexity Applications: Food & Environment Life Sciences and Pharmaceuticals Chemical

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Adding Cost Effective Mass Detection as an Orthogonal Technique for Improved Productivity and Confidence in the Analysis of Protein Biotherapeutics