Application Note: Adding Cost Effective Mass Detection as an Orthogonal Technique for Improved Productivity and Confidence in the Analysis of Protein Biotherapeutics
2 July 2015

This poster presents an analytical strategy for the acquisition of optical and MS based data necessary for the efficient monitoring of critical quality attributes (CQAs) associated with a mAb in a single cost-effective workflow. While optical detection provide some assurance, the use of an orthogonal detection technique like mass detection expands detection limits, improves specificity and increases confidence in peak homogeneity.