Application Note: A New Tool for Nano-Milling Poorly Watersoluble API Using the Precellys® + Cryolys
21 January 2015

The majority of approved drugs have poor solubility and permeability. Reducing the particle size and surface area of the API (Active Pharmaceutical Ingredient) increases drug performance and bioavailability. The Precellys®24 with Cryolys was validated for drug nano-sizing using different milling protocols.