Application Note: Validation of the New DRG Hepcidin Salivary ELISA
11 July 2018
Hepcidin is an iron homoeostasis regulator peptide. The bioactive peptide Hepcidin-25 is generated predominantly in the liver by proteolytic cleavage of the C-terminal 25 amino acids of prohepcidin. Subsequent N-terminal processing of Hepcidin-25 results in smaller peptides of 20-24 amino acids that show greatly reduced activity and accumulate in the urine. The application note evaluates the use of the DRG Salivary Hepcidin ELISA (SLV-6082), a solid phase enzyme-linked immunosorbent assay (ELISA) based on the principle of competitive binding.