Application Note: Particle Selectivity Difference Between CORTECS C8 and BEH C8 Columns
30 November 2018
Structurally similar compounds can be difficult to separate, making the development of rapid chromatographic methods for them very challenging. Changing the column stationary phase is one important tool to provide increased resolution. using smaller and/or solid-core particles can improve efficiency. However, another source of increased resolution can be the selectivity difference inherent in stationary phases. While it's most common to vary the bonded phase chemistry, selectivity differences may also be achieved by varying the base particles.