Low Propensity of Resistance Development Against Novel Combination Miconazole-Nisin (1:8) in Clostridium Difficile Strains Isolated from Humans

This poster describes how the anti-clostridial activity of the novel combination miconazole-nisin against toxigenic and non-toxigenic C. difficile strains was measured and reports on the absence of resistance development over a 14-day passage. The resistance development profile of this combination compares very favourably against vancomycin, the current treatment choice for severe infections caused by C. difficile.