Accelerating Science: How to cure the incurable with cell and gene therapy

Application Note: Introducing Onco-Hu mouse models
6 February 2024

In this application note, The Jackson Laboratory presents its research on humanized mice, specifically the comparison between NSG and NSG-SGM3 mice engrafted with CD34+ human hematopoietic progenitor cells (HPCs) from the same donor. The study evaluates the humanization levels in these mice and their efficacy in cancer models, particularly their response to anti-PD-1 therapy with pembrolizumab. The results suggest that PDX-bearing NSG-SGM3 mice could serve as an improved platform for preclinical immuno-oncology efficacy studies.