Application Note: The effect of column hardware on the analysis of synthetic oligonucleotides by LC-MS
23 May 2023

Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry. Improved reliability to synthetic routes coupled with new drug delivery technologies has given a heightened level of interest in these clinically interesting targets. In this application note from Phenomenex, learn how by minimizing non-specific interactions, the use of BioTi hardware not only serves to improve chromatographic performance and reproducibility of oligonucleotide separations, but also maximizes analyte recovery and sensitivity enabling both consistent quantitation and characterization.