Accelerating Science: How to cure the incurable with cell and gene therapy

Application Note: Single domain antibody development from ProSci
7 December 2023

Single domain antibodies (sdAbs), also known as VHH antibodies, are recombinant antibodies comprised of the binding domain from heavy chain only camelid antibodies. Due to their small size, ~15kDa, and their longer and structurally unique Complementarity Determining Region 3 (CDR3 region), they target unique epitopes inaccessible by conventional antibodies. This application note explores ProSci’s single domain antibody development service that offers two different packages: Premier – Immunization through library construction, and Pro – Immunization through final clones, as well as customized packages. The current catalog of ProSci sdAbs also includes antibodies to select immune checkpoint targets and SARS-CoV-2 spike glycoprotein S1 and S2 domains.