Application Note: High-throughput mass spectrometry analysis of synthetic oligonucleotides
22 November 2022

In this application note, Agilent Technologies describes and compares two methods, Fast LC and RapidFire, for the high-throughput sampling and desalting of oligos. Each method was optimized for speed on 18mers, then characterized for performance on a range of synthetic DNA and RNA, 18 to 100mer in length.