Application Note: Headspace analysis: reproducibility of syringe headspace injections for aqueous samples
5 May 2022

This application note describes the optimization of residual solvents analysis according to USP and Ph. Eur. 2.4.24 using the automated syringe headspace technique on GC-FID and GCMS systems. The precision of analysis ranged from 4.3 to 7.8 % RSD (GC-FID) for class 2 solvents for all analytes investigated in this study. These values fully comply with USP and Ph. Eur. 2.4.24 requirements.