Application Note: Advanced oligonucleotide analysis: Increased recovery and reproducibility with new bioZen Oligo
23 May 2023

Oligonucleotides can chelate to trace heavy metals in stainless steel column hardware, leading to poor recovery, inconsistent chromatography, and problematic carryover. In this application note from Phenomenex, explore the bioZen™ Oligo which uses bio-inert hardware to enhance the chromatographic performance and consistency of oligonucleotides, and providea improvements in sensitivity, enabling both quantitation and characterization. The bioZen™ Oligo Columns utilize organo-silica core-shell particles with a highly consistent morphology that minimizes band broadening associated with diffusion and mass transfer.