Application Note: A humanized platform for therapeutic antibody PK evaluation
5 April 2024

Evolutionary changes in the neonatal Fc receptor (FcRn) mean that regular wild-type mice cannot accurately predict how human therapeutic antibodies will behave. The Jackson Laboratory has created transgenic mouse lines with human FcRn, forming the HuPK platform. These models can predict how antibodies and other biologics will behave in humans. Various HuPK models exist with additional modifications to study specific aspects of drug behavior. The Jackson Laboratory provides an overview of the available models, study design templates, expected results, and troubleshooting tips in the context of the most common applications of its HuPK Platform.