LC troubleshooting - All of my peaks are tailing! What should I do?

28 April 2021

Tailing peaks can be a problem when doing liquid chromatography (LC), and secondary silanol interactions are one of the causes. Here, using the example of basic drugs, Restek explains what causes them and cover a few steps that can be taken to minimize the effect of these secondary silanols on peak shape when troubleshooting.