Multiplexed High Content Hepatotoxicity Assays using iPSC-Derived Hepatocytes
18 Sep 2012

Human hepatocytes derived from stem cells can greatly accelerate the development of new chemical entities and improve drug safety by offering more clinically relevant cell-based models than those presently available. Human induced pluripotent stem cell (iPSC) derived hepatocytes express appropriate hepatocyte markers and demonstrate intrinsic hepatocyte functions similar to primary cells. We demonstrate several models for assessing general and specific hepatotoxicity that are well-suited for automated screening environments.

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