VanGuard Column Protection Products by Waters

Manufacturer Waters  |  Available Worldwide
4.4
/
5.0
  |  81 reviews

Extend your LC column lifetime while maintaining chromatographic performance.


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VanGuard Column Protection Products
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Average Rating: 4.4
81 Scientists have reviewed this product

5 out of 5
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money


If not installed correctly they leak, then you've wasted several hundred dollars.
Rating: 4.0

  • Application Area: Measuring anticancer drug (and metabolites if necessary) in clinical samples of multiple biospecimen

"When installed correctly, the VanGuard guard columns work great. However, if not installed correctly, as it can be difficult to set the ferrule when there's loose, tiny parts that need arranged, then the column is useless and you've wasted money. training new employees is difficult because you're sometimes wasting thousands of dollars of 4-5 guard columns until they learn to do it correctly every time."

Review date: 04 Oct 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Soft Landing Labs



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
An easy to use product that provides maximum column protection.
Rating: 5.0

  • Application Area:LCMS urinalysis of Drugs of Abuse

"I use these columns on our Waters Aquity HPLC instruments and they are fantastic! They are easy to use and easy to install. There are even YouTube videos to help you out, with instructions on how to install the guard columns properly. They protect our columns for hundreds of injections and we do very little to clean up our urine samples. I highly recommend this product."

Review date: 04 Oct 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Canon Nanotechnologies



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
This product has prolonged column life saving time and money in the lab.
Rating: 4.0

  • Application Area:Analyze composition of raw and in-house materials produced.

"This product is effective in helping to prolong column life. It has been very useful especially for large molecule column build up and raw material contamination. The value for the money is in the fact that this product can prevent having to change the column as it acts somewhat like pre-column filter and costs less than the column. Once installed it is very easy to use but the installation can be a bit difficult to set the ferrule and not bend the rod inside. This can lead to leaking or having to use a new VanGuard. There is not much to after sales care for this product is a consumable."

Review date: 03 Oct 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: ECI Pharmaceuticals



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Good results, quality product
Rating: 5.0

  • Application Area:Pharmaceutical impurity test

"The column guard effectively protect our column and conform with USP specification in terms of size of guard column."

Review date: 02 Oct 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: National Institutes of Health



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
High benefit-cost ratio & reproducibility make Vanguard columns a good investment.
Rating: 4.7

  • Application Area:Analyze small molecules in human biological matrices.

"Vanguard guard columns are effective in protecting analytical columns for most bioanalytical applications, but are most effective and reliable when combined with an efficient and robust sample extraction method. This is most important when working with biological matrices. When followed by a robust sample extraction method, the Vanguard columns provide high quality results and reliable reproducibility. Vanguard pre-columns are easy to use, and can provide a high benefit-cost ratio to the laboratory when samples are processed efficiently."

Review date: 30 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Celgene Corporation



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Greet product extends column life.
Rating: 4.7

  • Application Area:Small molecule analysis

"Effective, easy to use, saves money by extending life of the column. Customer support of Waters is great."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: WHOI



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    3 out of 5
A necessary expense
Rating: 4.3

  • Application Area:Lipidomics

"You're not going to hook up your very expensive HPLC column without a guard column are you? So you've go to buy the (also expensive) guard columns and the bafflingly expensive guard column holder too. Suddenly buying a $700 column turns into a $1,100 shopping trip."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: BCPC



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
Good product; I wish it were more affordable.
Rating: 3.7

  • Application Area:Analyze drug concentration in urine

"It was easy to use the vanguard once the directions for its installation were followed. I like this product. However, I wish the product was less expensive."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Bruker



  • Ease of use
    5 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
Good product and it is easily connected with other brand columns
Rating: 3.7

  • Application Area:life sciences

"It is very easy to connect it with other vendor's columns and has a good quality to reduce matrix background . It is a routine guard column used in my method development and application."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Roosevelt University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great protection , extended the column life span.
Rating: 5.0

  • Application Area:Analyzing metabolites in protein samples

"Highly effective in achieving reproducible results. Easy to use. Protects our valuable “expensive” analytical column."

Review date: 29 Sep 2017 | VanGuard Column Protection Products


  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Columbia University



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    1 out of 5
Good for analysis and column lifetime
Rating: 2.7

  • Application Area:Analyze compounds in biological samples etc.

"It is good item but we feel it is expensive a little bit because we need to exchange it frequently. "

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Innogenix,Inc



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
Very good
Rating: 3.7

  • Application Area:for analytical method development of some products

"Product is very good. We have lot of applications with this product. This is a startup company so we may need lot of products from you in future."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Milliken & Company



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Great pre-column used to protect your columns
Rating: 4.7

  • Application Area:Analyze lab synthesized small molecules

"We use VanGuard Pre-columns for our Acuquity UPLC BEH C18 and UPLC HSS T3 columns. The pre-column is great. It is easy to install and has long lifetime. We are satisfied with VanGuard pre-columns. It is worth the money you spend."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: University of South Alabama



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
A must have!
Rating: 4.7

  • Application Area:Quantify analytes in various medium

"The column protection was easy to use. The column protection is an affordable and easy way to protect analytical columns."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Generic Drug Company



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great results, Can't live without this instrument
Rating: 5.0

  • Application Area:Analyse tissue samples

"It was very effective and I enjoyed the quick shipment"

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Woods Hole Oceanographic Institution



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Works perfectly with my Acquity UPLC columns.
Rating: 5.0

  • Application Area:LC-MS based metabolomics

"These VanGuard column protectors are extremely easy to use; no parts to assemble or leaking issues."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: University of Massachusetts Medical School



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Awesome product.
Rating: 5.0

  • Application Area:Hydrogen exchange mass spectrometry for protein folding

"I needed a column to survive tough experimental conditions which include high pressure and ice cold temperatures. BEH VanGuard columns suited my application best. I have been using these columns since a year. The results are impressive and reproducible. I am satisfied with my purchase."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Neogen



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
It's SO easy to use!!
Rating: 5.0

  • Application Area:Analyzing mold toxins in food commodities on HPLC

"The Vanguard guard columns are quite simply the easiest guard column to use. It's simply a matter of unscrewing the old one and screwing the new one in. There is no room for error in replacing these! Other styles have difficult housings to line up the cartridge in that can lead to leaking, but not the Vanguard. It's also fantastic at prolonging the life of the analytical columns. Simply amazing product!"

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Johns Hopkins University



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    3 out of 5
I would definitely recommend VanGuard Columns
Rating: 4.0

  • Application Area:Peptide Analysis

"I was very happy with the results. The LC was very reproducible."

Review date: 29 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Temple University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
VanGuard precolumns effectively protected my analytical columns from sample damage.
Rating: 5.0

  • Application Area:Analyze in vitro assay samples for compound concentration for drug discovery

"The purpose of the product is to protect expensive UPLC columns from damage due to contaminants in samples. I have used VanGuard precolumns for C18 and HILIC columns. They have done the job. I typically go through 3 precolumns before I replace the analytical column. Example: I recently had a precolumn/column that was producing high pressure. When I replaced the precolumn, the column behaved as if it was new. I was very happy. The precolumns are easy to install. Waters (especially the service technicians) have always been very helpful in answering my questions. I also appreciate the academic discounts since I work at a University and money is tight."

Review date: 28 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Clemson University



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
One of the best LC columns for metabolomics
Rating: 4.7

  • Application Area:Metabolomics

"We purchased an ACQUITY UPLC HSS T3 Column, (100Å, 1.8 μm, 2.1 mm X 150 mm) along with the VanGuard guard columns. Primarily we work with plant samples for metabolomics so the matrix is dirty with a lot of sticky compounds including lipids and polymeric tannins. Over the past 10 years we have used other reverse-phase columns and chemistry from Phenomenex, Agilent, Waters and Thermo. HSS T3 beats all others columns that we have tried in terms of peak shape, resolution, and in better retention of polar compounds, which makes post processing of the metabolomic data much easier. The column easily lasted >1500 injections with Vanguard cartridges being changed every 500 injection or so. These columns are a bit expensive but the quality is worth the price, and the vanguard protection is definitely a good investment for extended column life when working with dirty sample matrix. We currently are trying the new CORTECS T3 from waters (~1000 injections). It has been through pretty rough treatment in terms of sample matrix; so far so good! We definitely recommend both these products for untargeted metabolomics experiments."

Review date: 27 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: UNM



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
The column works great.
Rating: 4.7

  • Application Area:Dissolution

"I appreciate the after sales service. Thank you for the customer support."

Review date: 27 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Systemic Formulas



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    5 out of 5
Great product... once installed on the main analytical column.
Rating: 4.0

  • Application Area:Many different analytical applications

"I have always been a proponent of using guard columns to extent the life of analytical columns. The only criticism of the vangaurd product is the little black washer that holds the ferrule in place prior to installation. If you are careful with this product, and the washer is removed to son, it is very easy to loose the ferrule by dropping it on the floor. The vangaurd system work great once installed!"

Review date: 27 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: The university of oklahoma health sciences center



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great Results!
Rating: 5.0

  • Application Area:Analyze methabolites in tissue samples

"It is easy to use and i get reproducible results. I get sharp and narrow peaks."

Review date: 25 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Thomas Jefferson University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    3 out of 5
Good results
Rating: 4.3

  • Application Area:Bioanalysis

"We did achieve high quality in the peaks as we used this guard coluymn for the plasma samples."

Review date: 25 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: UNIVERSITY OF MISSOURI - COLUMBIA



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Very good guard column.
Rating: 4.7

  • Application Area:Guard column used in the analysis of metabolites in serum, tissue, and plant extracts

"The guard columns are easy to use and are robust. They have worked well for our analysis needs."

Review date: 25 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Carnegie Mellon University, Dept. of Chemical Engineering



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great protection thus far!
Rating: 5.0

  • Application Area:Natural products purification and identification

"Working with natural products, we were very worried about lifetime fouling or damage of our HPLC columns. So far, the Vanguard cartridges have been extremely successful in avoiding any loss of function in the columns!"

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: University of Illinois at Urbana-Champaign



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Very good product
Rating: 4.7

  • Application Area:analyze metabolites in plant extracts or biological samples

"POS: necessary in Waters column protection; very good performance in reproducible results; very easy to use. NEG: easily blocked and fast breakdown; kind of a high price."

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Soft Landing Labs



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Column life is very long when you are protecting with VanGuard. Definitely worth it!
Rating: 4.7

  • Application Area:Analyze metabolites in urine samples

"We use VanGuard columns and we will never change. They protect the column and preserve the life of the column so well. We are able run thousands of injections thanks to the protection it provides."

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Spectrix Analytical Services, LLC



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Good product!
Rating: 5.0

  • Application Area:ingredient analysis of plant samples

"It is very easy to use this product. The retention time of target peaks slightly changed compared to the run without VanGuard Pre-Column, so the modification of the method was not necessary. As a first time user, I hope that Waters could provide one or two additional Ferrules with the kit, because the Ferrules was loose on the new product, and easily got lost during the installation for a new user. I just started using this products for the purpose to extend the life time of main column during the 'dirty' analysis. So far, the analysis results are satisfying."

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: University of Utah - HSC Metabolomics Core



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Great performance for hundreds of injections.
Rating: 4.3

  • Application Area:LC/MS for targeted and untargeted lipidomics

"VanGuard columns have been the standard in our lab for targeted and untargeted lipidomics. Our chromatography is highly reproducible and very stable thanks to these products. As an academic lab that must keep an eye on our budget, we use these columns as long as possible - getting several hundred of injections before replacing them. The performance of these columns is very consistent - they don't gradually fail it seems to be all or nothing. As soon as we see any peak broadening (usually doubling) we know the precolumn has gone bad. This makes maintenance very easy."

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: ExxPharma Therapeutics LLC



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Good results but short life.
Rating: 4.7

  • Application Area:Drug product

"Good results when the guard is new however, gets clogged in relatively short period of time and starts to increase pressure"

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Advanced Chemical Sensors



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Must Have!!
Rating: 5.0

  • Application Area:Analyze Glutaraldehyde/OPA/Formaldehyde sample

"It is very easy to use connect & go. Peaks comes out much cleaner then without it. Worth the money."

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Ethicon



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
column works great!
Rating: 4.7

  • Application Area:used for analytical instruments in the lab

"The column was highly recommended by our chemist as a top rated product"

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: GlaxoSmithKline



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Good guard columns, easy to put on.
Rating: 4.7

  • Application Area:guard column for UPLC

"We use Van Guard columns regularly and they are easy to assemble. "

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF PHARMACY



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great Results
Rating: 5.0

  • Application Area:Tissue samples

"I did not use the product I only purchased product for our research assistants. But they said the product was good."

Review date: 21 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: West Virginia University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
We can now run roughly 10 times as many samples for the same price!!
Rating: 4.7

  • Application Area:Protect analytical column from damage by larger particles

"We used to go through guard cartridges every 200 runs or so. The Vanguard pre-column is amazing at protecting and preserving the life of the analytical column. We have run more than 2000 runs on the same analytical column and have only changed our Vanguard pre-column one time. Amazing! Slightly expensive."

Review date: 15 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: NIDDK, NIH



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
No problems. We may keep using VanGuard
Rating: 4.0

  • Application Area:Metabolites in plasma or urine

"We have just started to use it. No problems and we hope to protect the column longer"

Review date: 14 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Amgrn



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Great product
Rating: 4.7

  • Application Area:Mass spectrometry, LC seperation

"Very effective in salt removal and peptide capture"

Review date: 14 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2015

  • Organization: University of New Mexico



  • Ease of use
    2 out of 5
    After sales service
    2 out of 5
    Value for money
    3 out of 5
Useful but very cumbersome
Rating: 2.3

  • Application Area:This is in a service center

"Replacing these is cheaper than replacing columns, however, I find that integration with the downstream column is problematic. It takes sometimes hours to seat the VanGuard column into the the subsequent analysis column without the system leaking. Sometimes it is just easier to install a new VanGuard. I have taken to not using one unless I know the sample is going to be problematic. Paying $400 for one new functional VanGuard every six months is the same price as replacing the column once a year."

Review date: 14 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Xavier University of Louisiana



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    2 out of 5
Performs well; too costly
Rating: 3.0

  • Application Area:Analyze samples for stability study

"While the product performed as expected, the devices are too costly. A component of the samples cause a pressure increase. The pre-columns saved the main column. However I had to change several of these pre-columns. I was not able to clean them."

Review date: 14 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Pharma



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great product.
Rating: 5.0

  • Application Area:Assay and Impurity analysis of parenteral drug products

"The product is very easy to use and the scientist obtained better resolved results with the use of the guard column and extended the longevity of the column."

Review date: 14 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: University of Florida



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
Does not affect results.
Rating: 4.0

  • Application Area:Analyze metabolites in tissues

"This product does the job but is very expensive. Saves Columns."

Review date: 14 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: North Carolina State University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
You can use the column without the guard but since it is recommended, we use it!
Rating: 5.0

  • Application Area:Analyzing blueberry samples for anthocyanin content

"The product seems to work well. This product is supposed to protect the column and it appears so far that the column has not been damaged. I am not sure if there any way to see if the guard is working or not."

Review date: 13 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Oregon Health and Science University



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
User friendly and reliable.
Rating: 4.3

  • Application Area:Toxicology

"VanGuard precolumns are really easy to install and use in the Acquity UPLC system. I have 4 different column chemistries installed on my instrument and use a different precolumn for each. I've never encountered any issues with these. Each time a precolumn is installed chromatography is reproducible and reliable."

Review date: 13 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: CDC



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Large cost benefit; spend a little to save a lot.
Rating: 4.3

  • Application Area:Analyze metabolites in urine

"We currently use this guard column for a dilute-and-shoot urinary metabolites method. It has improved our column lifetime up to nearly double with very minimal impact on retention time or resolution changes. It is easy to use and tighten onto the analytical column, the worst part being the small ferrules and collets that can easily fall off. There is a rubber stopper in place, but including an extra ferrule and collet with the pack of 3 guard columns would be nice, just in case. Additionally, wrenches must be used to tighten the column, which is fine, but eventually creating some sort of hand-tightening mechanism would be ideal, because it is sometimes difficult to be sure you haven't under or over-tightened the guard column. Batch-to-batch variability has been minimal - some guard columns go faster than others, but this is most likely due to sample cleanliness."

Review date: 13 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Legend Technical Services



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Excellent product! Worth every penny and then some!
Rating: 5.0

  • Application Area:Extractable/leachable testing via UPLC/MS

"The adaptation of the holder to the system was flawless. There was no substantial peak shifting or drift due to the holder and guard cartridge and the system traps all the material that would otherwise get caught onto the column, thus the column life has increased 2 fold at least, cutting back on costs tremendously. The quick change capability of the system also allows for minimal down time."

Review date: 12 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: North Carolina State College of Veterinary Medicine



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great product. Highly recommended for any UPLC-MS-MS user!
Rating: 5.0

  • Application Area:Analyzing drug concentrations in plasma and lung fluid

"VanGuard columns have been instrumental in finishing my thesis. The products are well made, easy to use and reliable. The Waters customer service representatives are always helpful. Great product and company."

Review date: 12 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: MIT



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
Good value
Rating: 3.7

  • Application Area:Analyze dish samples

"Above average performance compared to other similar products"

Review date: 11 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: WHOI



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
A necessary expense
Rating: 3.7

  • Application Area:lipidomics, reverse phase

"Its crazy not to use guard columns, and so we buy them. The Vanguard format is pretty good, still wrestling with two wrenches to get them together, but seem to be leak tight and robust once they're on. Too expensive for a consumable, but cheaper than a trashed column."

Review date: 11 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: RTI International



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Great Results
Rating: 4.3

  • Application Area:Analyze formulations from corn oil

"Very easy to use. Saves column from degradation/clogging."

Review date: 11 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: CMIC, Inc.



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great Result
Rating: 5.0

  • Application Area:Sample Analysis through LC/MS

"We have used Waters columns from last 8 years and never had any issue with performance or results. Great product and customer services."

Review date: 11 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: GOJO Industries



  • Ease of use
    3 out of 5
    After sales service
    5 out of 5
    Value for money
    3 out of 5
Good for peak tailing, expensive, bump issue.
Rating: 3.7

  • Application Area:Analyze Benzalkonium chloride homologs

"The installation is easy and there are Youtube videos that help you install it however occasionally I see abump on my first eluting peak and it could be due to the installation. I have seen this with myself installing it and other technicians. This discouraged us to keep buying it. It is an expensive item, I think we are better off just replacing our C18 column. If we could figure out the issue with the bump, I might consider buying the item again. I liked that it helped with peak tailing."

Review date: 11 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Marrone Bio Innovations



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
Well designed column guard.
Rating: 4.0

  • Application Area:Analysis of metabolites from cell broth

"Column guard is easy to use and occupies less space than the old model."

Review date: 08 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Thomas Jefferson University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great Results
Rating: 5.0

  • Application Area:Bioanalysis

"Yes, I did achieve high quality. I was using plasma samples and it was really helpful to use the vanguard with the plasma samples. It is very user friendly and I will definitely recommend this to anybody."

Review date: 08 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Namco company



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great product.
Rating: 5.0

  • Application Area:Residual reactant

"Performed as well as it did for the developer of the method."

Review date: 07 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Cargill BioTRD



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Invaluable for Intracellular Metabolite Analysis
Rating: 5.0

  • Application Area:Intracellular metabolites

"The analysis of intracellular metabolites is complex and messy. However, the data generated is extremely important and the quality of the data is paramount. Strain engineers rely on the information to make decisions on which strains to bring forward, and fermentation engineers rely on the data to best optimize fermentation conditions to maximize titers of high value products. The addition of the Van Guard column to our analysis has allowed us to maximize the robustness, precision and accuracy of the analysis, while limiting the deleterious affects that matrix compounds have on the retention time and on the cleanliness of the MS detector."

Review date: 07 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: TOLMAR



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Purchasing and using this product was a breeze!
Rating: 4.3

  • Application Area:Small Molecule analysis

"I believe the results given for this particular column protector were useful for the method redevelopment in which it was used. Purchsaing the column protector and column from Waters was very easy as the Waters reps and website are useful and in my opinion, very user friendly."

Review date: 07 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Pharmaron



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    3 out of 5
I am sure we will be ordering this product again soon.
Rating: 4.3

  • Application Area:Analysis of peptide nucleic acid in plasma and tissue samples

"The VanGuard Column Guard worked well for our application in that it extended the lifetime of our analytical column. Without it, we would have seen peak degradation and retention time shifts much sooner. The VanGuard Guard Columns are very easy to use and install with the included instructions. As always, these things tend to be very expensive and eat into the cost of a run, but overall the value is there."

Review date: 07 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: University of Alabama Department of Nutrition



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Would definitely recommend this product configuration for use with biosamples!
Rating: 4.7

  • Application Area:Analyzing bioactive compounds in food matrix and serum, urine, and adipose application

"The guard was highly effective at decreasing our intra-assay noise. It eliminated any contaminants not removed from deproteination of samples."

Review date: 07 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Thermochem, Inc



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    2 out of 5
Good results and essential for our work, but becoming quite costly to replace
Rating: 3.0

  • Application Area:Analyze tracers in energy industry samples

"The guards work well to protect the column. Installing a new guard can be a bit tricky, the parts that are loose before attaching are easy to lose if you are not careful. The cost has jumped significantly in the last few years. They are not cost-effective when running conditions are harsh."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Sherwin Williams



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    3 out of 5
Works well yet a bit pricey
Rating: 4.0

  • Application Area:monomer and oligomer chromatography

"VanGuard columns (RP C18 and Hilic chemistries) effectively increase analytical column lifetimes by about 4X, allowing us to perform ~500 injections on an analytical column. In that time, we consume 2-4 VanGuard columns."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: GINKGO BIOWORKS



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
It works great but the design could be improved (e.g. in one more sturdy piece)
Rating: 3.3

  • Application Area:Analysis of metabolites from many diverse sources.

"This product is simple to use and works very well, allowing us to run large numbers of relatively dirty samples safely without risking our columns. I do not particularly like the current design in 2 pieces and I feel the previous model was superior."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Carnegie Mellon University



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Good guard columns
Rating: 4.3

  • Application Area:Oligonucleotide separation

"Good columns and easy to use. Safeguards the main column effectively. Lifetime could be improved."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Crown Toxicology



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Saves my column, saves money, increases result efficiency!
Rating: 5.0

  • Application Area:Pharmacokinetic Matricies

"The VanGuard column guards are an exceptional product. They've increased my column life from 8-10k analysis to over 18k, essentially doubling its life. The price is excellent, the customer service is also top notch. I also like to run a clean sample, I run SPE and along with my VanGuard precolumn, my instrument is protected from buildup and possible contaminants."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Kamat Pharmatech



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great! I need to use this for every project
Rating: 5.0

  • Application Area:uplc method devlopment of various projects

"The effectiveness of the product is very good, this product is very easy to use and setup, recommended to anyone."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Impossible Foods Inc.



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Good results
Rating: 4.3

  • Application Area:Peptide analysis

"I used it as an in-line desalting column for peptide analysis on a Thermofisher HPLC system. It works fine for that purpose. MS signal improved."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Catalent Pharma Solutions LLC



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Great results, Will buy again
Rating: 4.7

  • Application Area:Analyze metabolites in tissue samples

"Easy to use, accurate results and validations, price is worth for the use."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Particle Sciences, Inc.



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
Very helpful for dirty samples or small pore size columns
Rating: 3.7

  • Application Area:Pharmaceutical analysis

"Column protection products are very useful for samples with significant residual matrix, even after the use of small micron filtration. They are especially useful for UPLC, where column frits are much smaller than in traditional HPLC."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Biogen



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Excellent performance, the only type of guard that we rely on.
Rating: 5.0

  • Application Area:Trap peptides after pepsin digestion before analytical column

"Very easy to use, plug and play type of guard, we use it to trap peptides after on-column pepsin digestion before separation on an analytical column. The guard also serves as a tool to desalt prior to mass spectrometric analysis. Very reliable and reproducible results. Great value for the money!"

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Takasago Int'l (USA)



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Excellent product!
Rating: 5.0

  • Application Area:Food, flavor and fragrance product analysis

"Direct-to-column attachment makes it easier to use than many competitors. Guard columns are easy to change."

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: CDMO



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
We would use more if it cost less
Rating: 5.0

  • Application Area:Pharmaceutical Product Quality Control

"The guard column makes scientific sense and is valuable for column protection"

Review date: 06 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Kezar Life Sciences



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
Very good results, would use again.
Rating: 3.7

  • Application Area:Analyze metabolites in tissue samples

"Results were of high quality and reproducible over multiple tests. Not the cheapest but worth the money."

Review date: 05 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Institute For Advanced Learning and Research



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
It's a must have for any lab.
Rating: 5.0

  • Application Area:Analyzing tissue samples

"Very reliable product to use. Easy to care for and pricing is very good for quality."

Review date: 05 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Idaho State Dept of Ag/Idaho Food Quality Assurance Lab



  • Ease of use
    5 out of 5
    After sales service
    3 out of 5
    Value for money
    5 out of 5
Good product, definitely worth the money.
Rating: 4.3

  • Application Area:Pesticide residue analysis in foliage, soil, water, and crops

"We have found that the VanGuard column pre-columns extend the life of our columns tremendously. They are very easy to install, and definitely worth the money since we get so many more injections on a column."

Review date: 05 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Union University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Excellent product at a great cost
Rating: 5.0

  • Application Area:Purification of small organic molecules

"We have had great success with this product. Having the chemistry match the chemistry of the column is critical for our analyses. We have had no issues whatsoever with the product."

Review date: 05 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Iowa State University



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
Overall I would buy this product again.
Rating: 3.3

  • Application Area:Analysis of Glycopeptides

"The column is very easy to use and there is a straightforward method for using it. The separation we have seen is repeatable and enhances resolution. When asking for resin within the column to translate it to a nanoESI I did not get the help I wanted."

Review date: 05 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Eurofins



  • Ease of use
    3 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
You should consider using VanGuard as your pre-column protection
Rating: 3.7

  • Application Area:Food and food products

"Overall the guard column is a good thing considering the price for UPLC column. It does not add to back pressure and analyte retention. The only draw back is that it is the only place we get a leak. The analyst should have a good tools operation knowledge since two wrenches are required to tighten up the pre-column. We routinely use them."

Review date: 05 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Glycobia, Inc.



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Easy to install and performs well.
Rating: 5.0

  • Application Area:Protect HPLC column used to purify oligosaccharides

"It was easy to install and has worked well so far."

Review date: 05 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Ohm



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great results.
Rating: 5.0

  • Application Area:In quality control

"Easy to use, good quality for money, I like this product ."

Review date: 05 Sep 2017 | VanGuard Column Protection Products
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: REPCO



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Quality product
Rating: 4.0

  • Application Area:Water Soluble Vitamins

"Van Guard columns are durable in the environment that we are using them in. They are consistent and reliable."

Review date: 05 Sep 2017 | VanGuard Column Protection Products

VanGuard Pre-columns and Cartridges are optimized to protect and prolong analytical column lifetimes without compromising chromatographic performance. VanGuard Column Protection products are available in a wide selection of particle sizes and stationary phases making them ideally suited for the physical and chemical protection for all Waters analytical columns.

Product Overview

VanGuard Column Protection Products by Waters product image

VanGuard Column Protection Products

Manufacturer Waters  |  Available Worldwide

4.4 / 5.0 | 81 reviews