TOYOPEARL MX-Trp-650M Multimodal Protein Purification
TOYOPEARL MX-Trp-650M is a high capacity mixed-mode resin used for the purification of monoclonal antibodies and other proteins.
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TOYOPEARL MX-Trp-650M is a high capacity mixed-mode resin used for the purification of monoclonal antibodies and other proteins.
The multimodal resin maintains dynamic binding capacity (DBC) at elevated feedstock or buffer conductivities. Along with fast binding and elution kinetics, Toyopearl MX-Trp-650M minimizes the amount of WFI needed for either feedstock dilution, or column elution, leading to lower in-process pool volumes and higher throughput.
TOYOPEARL MX-Trp Features:
- Multimodal cation exchange resin
- High binding capacity for IgG and other proteins
- Tolerates high conductivity feedstocks
- Sharp elution peaks with mild conditions
- Excellent pressure/flow characteristics
Purification of biomolecules with chromatography techniques
Bioprocess chromatography is an effective purification technique and is key for the successful development and commercialization of new drugs, no matter whether biologic, biosimilar, or biobetter. Explore over twenty application notes covering aspects of biopharmaceutical purification such as capturing of antibody constructs, mAb aggregate removal using salt-tolerant IEC or hydroxyapatite, intermediate purification of bi-specific antibodies with a non-affinity platform using MXC and HIC, antibody-drug conjugates (ADC) purification on HIC resin, or separation of oligonucleotides on highly-selective anion exchanger.
