Thermo Scientific™ Q Exactive™ GC Orbitrap™ GC-MS/MS System

In this application note, drugs (e.g. Doxepin, Clomipramin, Bromperidol (containing trisubstituted N-atoms = tertiary amines and other TCA´s) have been investigated in serum in order to see the effects of certain glass qualities. The results are reported by reproducibility data using different types of 2 mL autosampler glass vials.

The distribution of rare isotopes at molecular scales offers many potential tools in environmental chemistry, geochemistry, biochemistry, and other disciplines. This scientific poster presents the results of an experiment to develop the Thermo Scientific™ Q Exactive™ GC Orbitrap™ instrument as a generalized tool for precise, accurate, rapid and sensitive measurements of molecular isotopic structures.

This study was aimed at developing a method based on GC-HRMS to confirm the presence of pesticides in food commodities, while studying the capabilities and limitations of the GC Q-Orbitrap.

This application note details the use of the Thermo Scientific™ Q Exactive™ GC Hybrid Quadrupole-Orbitrap™ Mass Spectrometer for the chemical profiling of whiskies for the purposes of quality control and authentication. Whisky is a premium spirit beverage that has become an economically important commodity in many regions of the world. As a result, counterfeiting and/or adulteration is commonplace and is a threat to the integrity of the industry. Therefore, it is essential that whisky producers use the available analytical technology to accurately and comprehensively characterize their products. The results demonstrate that the Q Exactive™ is an extremely effective tool for the chemical profiling of complex samples, delivering excellent mass accuracy for all components in a sample that leads to fast and confident characterization of samples regardless of the concentration of the component.

Obtaining mass spectrometer (MS) measurements with high mass accuracy is essential to providing the required selectivity in complex matrices and to increasing the confidence in compound identification and confirmation. For the former, obtaining a consistently high mass accuracy allows the use of very narrow mass extraction windows, taking full advantage of the instrument’s mass resolving power. For the latter, measuring the mass of a chemical with sufficient accuracy allows the chemist to predict the elemental composition and isotopic ratios to help identify the chemical structure of the substance. This application note demonstrates that, using the high resolution of the Q Exactive GC mass spectrometer, excellent mass accuracy is always available to the user, across a wide concentration range and in the presence of a complex chemical background.

The disinfection of drinking water is required in order to protect consumers from potential waterborne infectious and parasitic pathogens. Water is commonly treated by adding chemical disinfectants, such as free chlorine, chloramines, chlorine dioxide, and ozone. However, although very effective in removing disease-causing microorganisms, these disinfectants can react with naturally occurring materials in the water and can form disinfection by-products (DBPs) which can be harmful to human health. Explore the use of a novel gas chromatography (GC), coupled with high-resolution accurate mass Orbitrap™ mass spectrometer (the Thermo Scientific™ Q Exactive™ GC hybrid quadrupole Orbitrap mass spectrometer) for iodo-DBPs detection and accurate mass identification in chlorinated and chloraminated water samples.

Many chemicals produced by human industrial activities have a negative impact on the aquatic environment, even at extremely low concentrations. To measure such an effect, many environmental chemists aim to develop analytical methodologies that can identify a substance at the intended Environmental Quality Standard (EQS) level in complex environmental matrices, including biota. For this reason, the directive 2013/39/EU introduced in August 2013 provides a strategy to monitor pollution of water and biota for European Union member states. This strategy involves the identification of priority substances that pose a significant risk to the aquatic environment. This guide provides an overview of the different compounds to be monitored as well as potential analysis methods.

The European Water Framework Directive is a directive that commits all member states to actively control for a long list of environmental contaminants in all water bodes of the various member states. It lays down a strategy against water pollution, to be applied in all European Union member states, that involves identifying priority substances and monitoring different classes of contaminants; and it includes the first watch list. This guide explains the most appropriate analytical techniques for each class of contaminant to allow efficient and accurate analysis.

Beer is the most widely consumed alcoholic beverage in the world and the third most popular drink after water and tea. Beer is typically brewed from four basic ingredients: water, a starch source (e.g., malted barley) brewer’s yeast, and a flavoring agent such as hops. Many varieties of beer result from differences in these ingredients, the additives used, and the brewing process. Once a manufacturer has developed a popular product they need to ensure that they can reproduce it consistently, and in sufficient quantity, in compliance with any local & national regulations. It also needs to remain stable over the shelf-life of the beer. This application notebook presents a range of methods for reducing analysis time without compromising resolution, monitoring processes to determine flavor and stability and characterizing beer using metabolomics approaches.

Analytical laboratories are under ever-increasing pressure to deliver fast results, while maintaining the highest levels of accuracy and confidence. The majority of these laboratories rely on targeted analytical approaches, using both gas chromatography and liquid chromatography coupled to triple quadrupole mass spectrometry (MS) instrumentation. These techniques cover the wide range of chemical classes to be monitored at the required levels of sensitivity and selectivity. However, they are limited to those compounds in the target list and they require careful optimization of acquisition parameters for each compound. This application note explains how high resolution, full scan mass spectrometry provides a solution to the demand for detection and quantification of a growing number of compounds and the retrospective analysis of samples long after data acquisition.

Discover how the Thermo Scientific™ Orbitrap™ system is being used to highly selectively and robustly identify and quantify chemical and microbiological compounds in the analysis of a wide range of environmental sources.

Learn how scientists at Laboratori de l'Agència de Salut Pública de Barcelona are using gas chromatography coupled with high resolution mass spectrometry for low level pesticide detection in foodstuffs.

In this presentation, Paul Silcock, Senior Marketing Manager at Thermo Fisher Scientific, introduces the new Exactive GC Orbitrap GC-MS System. Learn how its highly selective non-targeted data acquisition can quickly analyze samples in food & beverage, pesticides and other routine testing environments.

Paul Silcock, Senior Marketing Manager at Thermo Fisher Scientific, explains how GC-MS orbitrap technology can revolutionize analyses in routine laboratories, including labs involved in metabolomics or food safety.

In this video, Carmen Ferrer Amate, EURL-FV, Universidad de Almería-Edificio de Química, explains why high resolution mass spectrometry is a highly selective and reliable technique that can be used to screen difficult matrices, like fruit and vegetable samples that have many components.

Paul Silcock, Senior Marketing Manager at Thermo Fisher Scientific, discusses how GC Orbitrap technology offers both qualitative and quantitative analysis, with untargeted acquisition and high selectivity. This enables detection of low level samples in complex matrices, which is very important for the pesticides field.

Watch this presentation by Rob Carter, Product Manager at the National Laboratory Service, to learn about their methodologies for analyzing environmental contaminants that meet new regulatory standards.

Paul Gribble, Technical Director at ALcontrol Laboratories, discusses the difficulties associated with detecting low concentration organic contaminants in water samples. He describes how advances in high sensitivity detection instruments are enabling these contaminants to be detected to regulatory standards.

Simon Ellison, Sales Support Manager for Chromatography and Trace Elemental products at Thermo Fisher Scientific, introduces the capabilities of the Hemel Hempstead laboratory facility. This centre of excellence enables scientists to solve their problem to improve results.

Watch this presentation by Paul Gribble, Technical Director at ALcontrol Laboratories, to learn about robust, high throughput methods for the detection of low concentration analytes in water.

Thermo Fisher and Newomics to optimize performance of high-throughput analytical workflows

Thermo Fisher and Biognosys to develop industry-leading mass spectrometry-based workflows for the efficient analysis of proteins in complex biological matrices

Thermo Fisher Scientific announces collaboration to improve workflows in protein-based clinical research studies with Evosep at ASMS 2019

Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer reinvigorates high-end protein research with expanded analysis capabilities

Thermo Scientific HR Multi-Attribute Method provides verified analytical workflow from development to manufacture of protein therapeutics

Thermo Scientific Orbitrap Exploris 480 mass spectrometer is designed for high-throughput biopharmaceutical and academic research laboratories

Thermo Fisher software suite delivers enhanced performance, usability and connectivity

Thermo Fisher Scientific launches new ultra-high mass range mass spectrometer at ASMS in San Diego

Read exclusive interviews from experts in healthcare settings around the world, to discover how mass spectrometry is improving clinical diagnostics

Enhancements to Thermo Scientific Orbitrap GC-MS Systems offer users unprecedented depth for comprehensive compound characterization