MALDI-8020 Benchtop MALDI-TOF Mass Spectrometer

Explore the analysis of antibody-drug conjugates (ADCs), combining antibody selectivity with small-molecule drugs for targeted cancer therapy. Using its MALDI 8020 Benchtop Linear MALDI-TOF Mass Spectrometer, Shimadzu demonstrates how to determine binding sites and characteristics of pseudo ADCs, created by binding low-molecular compounds to research antibodies. This method supports quality assessment and development of ADCs in pharmaceutical research.

MALDI-ISD fragmentation of nucleic acids provides successive fragment ions by simple cleavages and is a highly useful tool for simple sequencing of nucleic acids. This application note from Shimadzu describes an example of sequencing antisense nucleic acids by ISD fragmentation using a Shimadzu MALDI-8030 benchtop linear MALDI-TOF mass spectrometer.

In this application note, Shimadzu demonstrates the capability of its imaging platform to easily achieve quality mass spectra and MS images for intact proteins from tissue sections and for peptides following on-tissue digestion, with linear mode analysis of rat brain tissue.

This application note from Shimadzu introduces an example of simple and rapid identification of vegetable oils, using a benchtop MALDI-TOF MS and the eMSTAT Solution statistical analysis software.

In this application note, Shimadzu examines the possibility of determining the state of cells by mass spectrometry by conducting an automatic analysis of iPS cells and their culture media by AuraSolution™ using the Shimadzu MALDI-8020 benchtop linear MALDI-TOF mass spectrometer.

In this application note, Shimadzu introduces a quantitative analysis method for the analysis of animal hair fibers using a MALDI-8020 benchtop MALDI-TOF MS.

Clinical drug tests are used to analyse biological specimens, for example urine, hair, blood, breath, sweat, or saliva to determine the presence or absence of a specified drugs or related metabolites.

New sample clean-up methods for human tear uid were evaluated for a MALDI-TOF MS-based biomarker investigation approach. Additionally, a unique MALDI matrix was used to ionize hydrophobic peptides and proteins in tear.

The applicability of MALDI-TOF mass spectrometry to perform protein detection is well recognized in the life science field. In this field, SDS polyacrylamide gel electrophoresis and size exclusion chromatography have been historically used, however, they have drawbacks such as being time-consuming or lacking accuracy in molecular weight determination. Due to its ability to provide more accurate molecular weight information, MALDI-TOF mass spectrometry has become the primary tool for the analysis of protein primary structures. Moreover, in recent years, the analysis of proteins at the femtomole and subfemtomole levels is often required, which is increasing the demand for higher sensitivity measurements with MALDI-TOF mass spectrometry.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometers (MALDI-TOF MS) feature simple and rapid detection of low molecular to high molecular weight compounds in a wide range of samples. MALDI-TOF MS is widely used to determine molecular weights of synthesized products and natural substances in R&D laboratories and quality control sectors. In addition, utilizing the feature of MALDI-TOF MS which can detect multiple components in a wide mass range as singly-charged ions (1 component = 1 peak), an attempt is being made to use the instrument for profiling property changes of food and biological specimens.

Forensic spectroscopy encompasses a suite of analytical techniques designed to identify unknown substances and quantify trace elements with extreme precision and speed. In this SelectScience interview, Dr. Tom Spudich, Professor of Analytical Chemistry, explores how advanced tools like UV-Vis spectroscopy, GC-MS, FTIR with ATR, and ICP-OES are transforming forensic science workflows.

Discover how these methods are instrumental in diverse applications, from preserving historic documents through elemental analysis to detecting beverage adulterants like 1,4-butanediol. Learn how Shimadzu’s high-sensitivity instrumentation is slashing analysis times from hours to just 15 minutes, significantly boosting sample throughput and accessibility in the field.

Find out more information on Shimadzu forensics solutions here.

This video guide provides all you need to know about the MALDI 8020 Benchtop Linear MALDI-TOF Mass Spectrometer, including features and applications.