Isothermal titration calorimetry is a universal bioassay system for measuring the activity of all biomolecules free and in solution. Millionths of a degree change in temperature occur when biomolecules interact. These can be detected by ultrasensitive calorimeters and used to precisely determine the kd of an interaction. The main advantages over other techniques are that there is almost no assay development because heat generation is common to practically all biomolecular processes and no labelling, immobilisation or other potentially damaging chemistry is required. It can also be used with DMSO or most other organic solvent systems.
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