The IRDye HA Optical Probes, IRDye 800CW HA and IRDye 680RD HA may be used to target the lymphatic system and those tumors over-expressing CD44 receptors.
Hyaluronan (Hyaluronic acid; HA) is an extracellular matrix glycosaminoglycan formed from disaccharide units containing N-acetylglucosamine and glucuronic acid. Hyaluronan interacts with several cell surface receptors, namely CD44, RHAMM (receptor for Hyaluronan mediated motility; CD168), LYVE-1 (lymphatic vessel endothelial Hyaluronan receptor-1), HARE (Hyaluronan receptor for endocytosis), layilin, and Toll-4. It binds to proteoglycans in cartilage and other tissues and fills an important structural role in the organization of the extra-cellular matrix. The agent is catabolized by receptor-mediated endocytosis and lysosomal degradation after transport via the lymph to lymph nodes.