The HP D300 Digital Dispenser is an automated benchtop instrument that uses HP’s Direct Digital Dispensing technology to enable rapid delivery of picoliter to microliter sample volumes to create dose response curves (IC50/EC50) for small molecule compounds.

Available exclusively through Tecan, this innovative device can cut titration times from hours or days to just minutes.

The HP D300 provides fast and reliable performance across a large dynamic range, eliminating the need for slow, error-prone and wasteful serial dilutions. Using disposable dispenseheads to avoid cross¬-contamination, the instrument offers complete freedom for non-contact dispensing from 13 pl to 10 μl, delivering any dose to any well and virtually eliminating waste of valuable compounds. It combines ready-to-run, walk up and use convenience with intuitive experiment design software to increase productivity while giving reliable results.

Even the most complex experimental plate layouts, such as drug-drug interaction (synergy) studies, can be made simple. Titrating one drug down the plate while another is titrated orthogonally across the plate enables two or more drug doses to be independently generated in every well. In addition, plate layouts can be randomized to reduce the impact of edge effects, increasing the integrity of the experimental data. The HP D300 Direct Digital Dispenser offers a convenient solution to address the most challenging experiments.