DynaPro Plate Reader III Dynamic and Static Light Scattering Detector by Wyatt Technology Corp.

Manufacturer Wyatt Technology Corp.  |  Available Worldwide
4.7
/
5.0
  |  19 reviews

Automated characterization of size, stability and molecular weight in industry-standard microwell plates


DynaPro Plate Reader III Dynamic and Static Light Scattering Detector by Wyatt Technology Corp. product image
DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
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Average Rating: 4.7
19 Scientists have reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money


Very useful instrument for protein quality control
Rating: 5.0

  • Application Area: Protein Research and development

"The first DLS instrument that enables high-throughput sizing and screening of pharmaceutical and nanoparticle formulations and only requires low sample amount."

Review date: 16 Apr 2018 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Intellia



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Indispensable for understanding protein behavior in a variety of conditions
Rating: 5.0

  • Application Area:Protein Preformulation

"Great product. Generally easy to use and the instrument almost never needs maintenance or repair."

Review date: 16 Apr 2018 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Fujifilm Diosynth Biotechnologies



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great Instrument - much better and faster than anything else on the market!
Rating: 5.0

  • Application Area:Protein Formulations

"I use the DynaPro Plate Reader III for biophysical characterization and protein formulations. Our lab used to make DLS measurements with a Zetasizer which required a new cuvette and fairly large volume for every sample. Because the DynaPro measures samples in a well plate, the throughput is much higher, and the sample volume requirement is much smaller. In my experience, the data quality from the Wyatt Plate Reader is superior to other DLS manufacturers. Highly recommended!"

Review date: 16 Apr 2018 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Boehringer Ingelheim



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Convenient reliable DLS for protein biophysical and nanoparticle characterization
Rating: 4.0

  • Application Area:Protein and VLP Biophysical Characterization

"The plate reader has been a very reliable instrument that delivers high throughput data with a quality close to the theoretical limit for the analysis. When used properly the data is very reliable. Wyatt does a good job offering training and technical notes to help scientists learn how to properly collect and use the data. Love the camera to check for bubbles, mis-filling or precipitation events. Within the expected accuracy and resolution of the method, the information on diffusion coefficients and estimates of nano-particle sizes are very valuable."

Review date: 24 Jul 2017 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: OUHSC



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Easy to use, and gives great results in various applications
Rating: 4.3

  • Application Area:RNA and protein characterization

"The Plate Reader is very user-friendly, and the ability to use low volume microplates (conserving precious sample) is a definite plus."

Review date: 21 Jul 2017 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Lund University



  • Ease of use
    5 out of 5
    After sales service
    3 out of 5
    Value for money
    5 out of 5
Changed the way we think of DLS. Use it to screen large sets of conditions
Rating: 4.3

  • Application Area:Nanoparticle characterization in protein rich media

"Changed the way we think of DLS. Use it to screen large sets of conditions"

Review date: 21 Jul 2017 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Merck



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great value for kD, B22, and formulation scan.
Rating: 5.0

  • Application Area:Protein Characterization

"We have purchased several of analytical instruments from Wyatt. The technical service is superb. Wyatt team of engineers have supported us with technical questions for many year. Best customer service for instrumentation."

Review date: 20 Jul 2017 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Agensys, an Affiliate of Astellas Pharma



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Great results, easy to use, high throughput and user friendly.
Rating: 4.7

  • Application Area:Analysis of mAb and ADC proteins

"This non chromatographic method for size variant analysis is a very useful technique and DLS has provided very valuable data for us. It is easy to use, rapid, high throughput and very sensitive method. Once you know how to interpret the data this could be a very valuable tool to any protein analytical and formulation lab."

Review date: 20 Jul 2017 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Pfizer



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Excellent instrument for characterizing proteins and small molecules.
Rating: 5.0

  • Application Area:analysis of proteins and small molecules

"We use our plate reader all the time. It's and excellent way for us to characterize the reagents and compounds we are working with. We have also used this to scout buffer conditions during assay development. We find the DynaPro plate reader to be very helpful in our drug discovery efforts."

Review date: 20 Jul 2017 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Osaka University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
We love to use this instrument always.
Rating: 5.0

  • Application Area:Therapeutic Proteins, Formulation development

"We have been used Wyatt Plate Reader for more than 6 years for formulation developments. Basically it is easy to use and provides good data."

Review date: 20 Jul 2017 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector


  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Ablynx



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Good, reliable and easy in use
Rating: 4.0

  • Application Area:high-throughput screenings, aggregation onser determination, Kd determination

"Good instrument to perform buffer screenings and rankings of leads. Makes it possible to stress a sample in different buffers and analyze it fast. good for selecting the right buffer!"

Review date: 20 Jul 2017 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Expert Reviewer

  • Member since: 2015

  • Organization: Ajinomoto Althea



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Huge time saver, able to generate data quickly under many varied conditions.
Rating: 5.0

  • Application Area:Rapidly screen aggregation state and purity of protein samples

"This is the first instrument we go to when receiving or generating new samples in our lab- we quickly have an assessment on purity, which lets us plan our subsequent experiments. It is non-intrusive, and the sample can be recovered. Programmed data collection and temperature ramping facilitate rapid acquisition of data under multiple conditions."

Review date: 20 Dec 2016 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Fraunhofer CMB



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great high-throughput DLS Plate Reader!
Rating: 5.0

  • Application Area:Analyze solution properties of protein targets.

"In using the Wyatt Plate Reader for our protein applications, we have seen very reproducible results over large time-spans (multiple years). The plate reader is very easy to use. After reading the user manual, speaking to technical representatives and reviewing the data interpretation guide, I was able to generate data quickly and reproducibly. The plate reader is excellent for high throughput applications in batch mode. The software is very user-friendly and I was able to start using the instrumentation quickly. The Wyatt technical team is excellent in both their knowledge and their response times. I am always able to get help in a timely manner that does not impede project timelines. Because of Wyatt's excellent service, I believe that any Wyatt product (including the Plate Reader) is a good value for the money invested."

Review date: 20 Dec 2016 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Emory University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great results, really helpful to analyze protein size and uniformity
Rating: 5.0

  • Application Area:Analyze purified protein complex

"Very effective in protein size and uniformity analysis. High quality and reproducible results. User friendly. When we got this instrument, the application scientist from Wyatt immediately taught us how to use this instrument properly. When I do a measurement, it only takes about 15 mins. Great company and instrument "

Review date: 29 Jun 2016 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: University of California, Los Angele



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great instrument, true high throughput!
Rating: 5.0

  • Application Area:Analyze nanoparticle sizes in water, biological, and environmental systems

"The plate reader is very easy to operate and offers a true high throughput analysis, which allows us to perform hydrodynamic size, size distribution, and agglomeration/dispersion state measurements for over 100 nanomaterials in a big variety of cell culture media and water systems. It generates data of high quality and high reproducibility. The built-in kinetics feature also allows systematic agglomeration kinetics measurements, which is essential in understanding the nanoparticle behavior under different testing conditions."

Review date: 29 Jun 2016 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: UCB Pharma



  • Ease of use
    4 out of 5
    After sales service
    2 out of 5
    Value for money
    3 out of 5
For routine use but not for challenging measurements.
Rating: 3.0

  • Application Area:Protein aggregation

"The plate reader is easy to use but shows some drawbacks. Reproducibility is too low. We use the equipment in routine measurements but unfortunately often have to double check the results with the Mobius DLS. Temperature range, up to 70°C, is too low to characterize thermal (aggregation) stability. Equipment has shown already several breakdowns. The latest was because of dirty optics although it had hat just before a maintenance. It took quite long for Wyatt support to figure out what the problem was and repair costs were unreasonable high."

Review date: 28 Jun 2016 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector

Manufacturer's Response

Dear Dr. Massant, Thank you for your valued feedback. We are pleased to learn that you use the DynaPro Plate Reader routinely as well as the Möbius zeta potential and DLS instrument. Since you are experiencing some difficulties, a Wyatt application expert will contact you in order to examine instrument performance, provide any additional guidance, and help you be more successful with your DynaPro. We are also pleased to report that the DynaPro Plate Reader II (a newer model than the one you own) is more robust and has an extended temperature range, up to 85C, which should address just about all of your protein stability needs. Sincerely, Wyatt Technology Corp.
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Pfizer



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Overall, good instrument with good support
Rating: 5.0

  • Application Area:Analyze diffusion coefficients of mAbs in various formulations

"This instrument is extremely easy to use. For our purposes in measuring diffusion coefficients of various mAbs in their formulations, it suits our purposes. Our final goal is to achieve a kD value for each mAb, which is a somewhat qualitative effort rather than quantitative. For this reason, I have been less concerned with some slight variability in the diffusion coefficient results. Sample contamination is very common as well, which can lead to less accurate readings, so sample preparation becomes very important. Support from Wyatt employees, whom I have met through training and conferences, has been very good. Some slight confusion has been raised over which diffusion coefficient values to use in the generated data. This is due to multiple views of the data which each give different values. This has been slightly concerning, but not a show stopper for our purposes thus far."

Review date: 23 Jun 2016 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Pfizer



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great instrument to have in the lab
Rating: 5.0

  • Application Area:Analyze aggregates from protein solution and compounds

"The instrument is very easy to use and maintain. It is a routine instrument in the lab to check protein and small molecule aggregates without any loss of samples."

Review date: 23 Jun 2016 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector
  • Status:

    Reviewer

  • Member since: 2015

  • Organization: UCL School of Pharmacy



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Low volume and high sensitivity
Rating: 4.3

  • Application Area:Antibody particle size

"I had a great experience working with DynoPro plate reader II to determine the particle size of my antibody. The great thing is about this instrument is a low solution volume needed for size determination with great sensitivity. "

Review date: 23 Jun 2016 | DynaPro Plate Reader III Dynamic and Static Light Scattering Detector

Speed up size and stability screening with high-throughput dynamic light scattering

Revolutionize your biotherapeutic and nanoparticle development with high- throughput dynamic light scattering (HT-DLS) and the automated DynaPro® Plate Reader III. The DynaPro excels at high-throughput sizing and screening of biopharmaceutical and nanoparticle formulations to enable novel workflows that simply would not be possible with other DLS instruments.

The DynaPro® Plate Reader III offers a complete solution in a standard well plate

  • Discover small-molecule and peptide drugs
  • Develop stable biopharmaceuticals
  • Formulate nanoparticles
  • Optimize protein buffers

Obtain the Complete Attribute Landscape

  • Size and size distributions (rh)
  • Molar mass (Mw)
  • Aggregation and stability indicators (Tonset, Tm, Tagg, kD, A2)
  • Viscosity
  • Solubility

Fast, Easy, Accurate

  • Uses industry-standard 96, 384 or 1,536 microwell plates
  • Sample volume as low as 4 μL
  • User friendly experiment design in Dynamics
  • As sensitive as a cuvette-based DLS
  • First and only A2 and Mw in a plate
  • Film- or oil-based evaporation seal
  • Measure from 4º to 85ºC
  • Infrared wavelength not susceptible to fluorescence
  • 21 CFR Part 11 compliant software

Product Overview

DynaPro Plate Reader III Dynamic and Static Light Scattering Detector by Wyatt Technology Corp. product image

DynaPro Plate Reader III Dynamic and Static Light Scattering Detector

Manufacturer Wyatt Technology Corp.  |  Available Worldwide

4.7 / 5.0 | 19 reviews