CyBio Well Vario - The Pipetting Work Horse
The CyBio Well vario is an automated, simultaneous pipetting platform designed for high-throughput screening environments. It combines exceptional flexibility with consistently high precision across a broad range of applications.
CyBio® Well Vario
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Good, solid instrument. Limited 384 pipetting volume.
Small Volume Liquid Handling with Research Samples
We have had our Cybi-Well Vario for more than 10 years now. It used to be our go-to instrument for library reformatting from 96-well to 384-well microplates. It takes just a couple of minutes to switch between the 96-channel and 384-channel heads which is very useful. As an accurate pipettor, it is our best in the lab. You ask for 2uL transfer, and that is what it gives you with great CVs. It is also very dependable. As one of our older instruments, we have a version that has a maximum pipetting volume of 25uL on the 384-well head. We find this to be limiting compared to some of the more recent pipetting platforms out there. It appears that they now have a 60uL head option, which would be recommended. Our other system can transfer up to 70uL with its 384-well head, and that has made it more attractive for many applications. One thing that I particularly like about the Vario is that it is user-friendly. We can have users of the facility use it, because there is little chance of damaging the unit when pressing on the tips. On our other platform, if the tips are not aligned properly, it can severely damage the head. On the Vario, that is not an issue. We used to be able to get 3rd party tips (Thermo/Matrix) for the instrument but I am not sure if these are still available. They were kind of expensive. PROS: (1) It is very accurate and precise (2) Very dependable instrument (3) Easy to use (4) Hard (but not impossible) to break. CONS: (1) 25uL pipetting volume head is quite limiting (2) It's a little slow (3) Tips are/were somewhat expensive. If you are looking for a dependable pipetting platform to run day in and day out, this is a good option.
Review Date: 1 Nov 2017 | Analytik Jena GmbH+Co. KG
Parallel Transfer for Isotopic Assays
This is a great instrument, easy to program and very reliable. It is easy to service which is important in an environment using isotopes. It has a good range of volumes. Regarding the service care, we have had little experience as it never seems to need any!
Review Date: 17 Feb 2014 | Analytik Jena GmbH+Co. KG
A great system that can do a wide variety of assay setups with little transfer time between them.
Review Date: 7 Apr 2009 | Analytik Jena GmbH+Co. KG
Excellent support provided.
Review Date: 4 Apr 2008 | Analytik Jena GmbH+Co. KG
CyBio Well vario – Flexible, high-throughput pipetting for demanding screening applications
The CyBio Well vario is an automated, simultaneous pipetting platform designed for high-throughput screening environments. It combines exceptional flexibility with consistently high precision across a broad range of applications.
At the core of the system is a modular concept with a wide selection of interchangeable pipetting heads. These can be easily exchanged from the front or back of the instrument without recalibration, as the system automatically detects the installed head. This enables seamless adaptation to changing workflows while maintaining reproducible results.
The platform supports simultaneous pipetting in 96-, 384-, and 1536-channel formats, enabling true high-throughput processing. A volume range spanning four orders of magnitude (from 25 nL up to 250 µL) can be covered on a single system by using different pipetting heads, disposable tips, or capillaries.
Advanced pipetting and tip sealing technologies ensure outstanding precision and reproducibility across the entire volume range, including reliable nanoliter dispensing with dedicated capillary heads.
The CyBio Well vario is designed for maximum adaptability: it integrates easily into diverse screening environments and can be extended with a variety of accessories, such as stackers or additional devices. This allows the creation of fully automated liquid handling platforms tailored to specific applications and future requirements.
Powered by the intuitive CyBio Composer software, users can easily set up and control applications, simplifying workflow development and execution.
Benefits at a glance
• High flexibility through interchangeable pipetting heads
• Broad volume range from 25 nL to 250 µL on a single platform
• True high throughput with up to 1536-channel simultaneous pipetting
• Proven pipetting and tip sealing technology for highest precision
• Reliable nanoliter dispensing with advanced capillary technology
• Easy application setup with CyBio Composer software
• Scalable system concept with extensive accessory integration
Brochures
Analytik Jena MALDI sample preparation configuration overview
Discover the Analytik Jena MALDI Sample Preparation configurations. The Analytik Jena MALDI Sample Preparation is the tailored and automated uHTS MALDI sample preparation for powerful and unique label-free detection capabilities of Mass Spectrometry.
Integrated uHTS MALDI Sample Preparation and Mass Spectrometry with Analytik Jena and Bruker’s timsTOF MALDI PharmaPulse
Discover the collaboration between Analytik Jena and Bruker, bringing you a cutting-edge liquid handling automation solution tailored for drug discovery screening. This innovative system integrates Bruker's MS System timsTOF MALDI PharmaPulse® with Analytik Jena's automated ultra-high throughput screening (uHTS) MALDI sample preparation. It provides a seamless combination of label-free mass spectrometry detection and high-efficiency sample processing.
Multiple Heads on a Solid Base: CyBio® Well vario
The CyBio® Well vario is an automated, simultaneous pipetting platform, which accepts a series of different interchangeable pipetting heads, thus combining high flexibility with upgradeability for future tasks at a reasonable price.
Precision of the CyBi®-Well Vario Nanoliter Head 384/2.5μL
In this application note, the CyBi®-Well vario Nanoliter Head 384/2.5μL was used to determine the liquid handling precision with fluorescence readout in the low volume range, using buffer and DMSO in the wet-to-wet liquid transfer mode. The CyBi®-Well vario has six pipetting heads which allow for fast and precise simultaneous pipetting whilst providing reliable handling of different liquids over a broad volume range.
Start-up Routine and Tip Washing Efficiency Data of the Active Deep Well Tip Wash Station 384
In this application note the tip washing efficiency of the active deep well Tip Wash Station 384 was determined quantitatively with optimized pump settings and different washing liquids after different numbers of washing cycles using a fluorescence read-out. Furthermore the start-up routing for the active deep well Tip Wash Station 384 was described in detail.
Precision of the CyBi®-Well vario 96/25 µl Head
In this study the CyBi®-Well vario 96/25 µl pipetting head was used to determine the liquid handling precision with a fluorescence readout over a broad volume range using different pipetting modes, different disposable tips and liquids with different surface tensions. The data show the excellent pipetting performance of the CyBi®-Well vario 96/25 µl pipetting head under various conditions and provide a tool that supports the choice of the right experimental settings and disposable tips or a broad range of customer specific applications.
How to Perform High Throughput siRNA Transfections with the CyBi®-Well Vario Workstation
In the field of gene silencing, RNA molecules of 21-28 base pairs in length are used for the inhibition of gene expression in mammalian cells because long dsRNA molecules induce the mammalian interferon response. These molecules are termed small interfering RNA (siRNA). One effective method for delivery of siRNA into cells is transfection through lipofection. This method is believed to be especially effective in the cell growth phase. This is achieved by forming a transfection complex of siRNA and a cationic lipid-based transfection reagent which is then incubated with cells to deliver the siRNA molecule into the cytoplasm. This poster demonstrates the suitability of the CyBi®-Well Workstation for automated dispensing of samples for siRNA lipofection.
Measuring the Precision and Accuracy of the CyBi®-Well vario 384/25 μl Head using the ARTEL Multichannel Verification System (MVS®)
The accuracy and precision demands of liquid handling tasks are growing with increasing throughput and decreasing volumes. In this study the sophisticated and well accepted ARTEL Multichannel Verification System (MVS®) was used to evaluate the precision as well as the accuracy of the 384/25μl head of the CyBi®-Well vario, one of the most frequently used pipetting heads of CyBio´s flexible simultaneous pipetting platform.
Automated TRANSIL<sup>®</sup> HSA Binding Kit on CyBi-Well® Vario
This application note describes the HTS set-up of the ADME/Tox determination of human serum albumin binding using TRANSIL® HSA Binding Kit and the CyBi-Well® Vario with the 384/25 µL head.
Revolutionize drug discovery with high throughput mass spectrometry and automated pipetting
Analytik Jena and Bruker have collaborated to bridge the gap between mass spectrometry’s powerful, label-free detection capabilities and modular automated uHTS sample preparation.
Join Dr. Christian Klinner, Analytik Jena, Arndt Asperger, Bruker Daltonics and Amanda Weaver, Biodesix, and as they discuss how the CyBio Well Vario pipetting device by Analytik Jena enhances MALDI spotting and sample optimization, seamlessly integrating with Bruker MS solutions to overcome application-specific bottlenecks.
Key learning objectives
- Learn how to increase your MALDI throughput, MALDI spotting of 1536 samples in <10 minutes
- Discover how to successfully overcome hardware, software and labware challenges
- Gain insights into a walk away automation solution for MALDI-TOF-MS
Who should attend?
Users looking to automate their MALDI-TOF sample prep
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
Transfer Compounds Directly from Stock to Assay Ready Plates
Watch this SelectScience.tv interview at Drug Discovery 2009 (ELRIG) to learn how to enhance precision and reproducibility with CyBio’s Capillary Well Vario System. This system has a multi-channel capillary head and stackers to increase throughput and provide automated washing or barcode reading. Heads are also changeable from capillary to microlitre, allowing transfers of larger volumes.
