Bio-Plex Pro RBM Kidney Toxicity Assays

Manufacturer Bio-Rad
  |  2 reviews

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Average Rating: 4.5
2 Scientists have reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money

Rating: 5.0

  • Application Area: clinical trial

"A very sophisticated product, easy to use and good value for money. Plus you get the renowned after-sales service of Bio-Rad."

Review date: 27 Aug 2014 | Bio-Plex Pro RBM Kidney Toxicity Assays
  • Status:

    Expert Reviewer

  • Member since: 2013

  • Organization: JRFAmerica

  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Rating: 4.0

  • Application Area:Enzyme Toxic Effect Metabolism Chemistry

"As a teaching tool it is very good and useful. It is an easy kit to use, its self explanatory and well developed. It is very useful as a marker to enzymatic effects from certain compounds. I've recommended as a very useful laboratory tool."

Review date: 11 Jul 2014 | Bio-Plex Pro RBM Kidney Toxicity Assays
The Bio-Plex Pro RBM kidney toxicity assays, developed in partnership with Myriad RBM, comprise a highly relevant set of biomarkers for early detection and characterization of kidney toxicity/injury. Myriad RBM’s close collaboration with the Predictive Safety Testing Consortium (PSTC), FDA, and European Medicines Evaluation Agency (EMEA) was instrumental in the selection of markers found in these panels.

The assays are built on magnetic beads to enable robust quantification of multiple proteins in human urine samples, providing valuable information throughout drug development — from lead optimization to preclinical and clinical protocol decision making. Assays are offered as premixed all-in-one kits for research involving:

• Drug-induced kidney toxicity
• Diabetes
• High blood pressure
• Glomerulonephritis
• Polycystic kidney disease
• Chronic infection
• SLE (lupus) and other autoimmune disorders

Bio-Plex Pro RBM human kidney toxicity assays are available as two panels:

Panel 1
• Calbindin
• Clusterin
• GST-π
• IL-18
• KIM-1
• MCP-1

Panel 2
• Albumin
• B2M
• Cystatin C
• Osteopontin
• TFF3

Based on 6.5 µm magnetic beads, these assay panels are compatible with both vacuum and magnetic wash stations. Magnetic washing simplifies plate processing, provides increased throughput, and results in decreased variability and increased reproducibility.

Key Features
• Optimized for high precision and lot-to-lot reproducibility of sample measurements
• Magnetic beads for simplified plate processing
• 2-level quality controls with lot-specific ranges
• Assay quick guide to get you started right away
• High-quality design ensures robust and reproducible measurement of nephrotoxicity biomarkers in human, rat, and canine urine samples

Premixed all-in-one kits

Instrument Compatibility
• Bio-Plex® MAGPIX™ multiplex reader
• Bio-Plex® 200 systems
• Bio-Plex 3D suspension array system
• Bio-Plex Pro wash stations