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SPT Labtech and RevoluGen demonstrate fully automated bead-based high molecular weight DNA extraction

SPT Labtech

The collaboration delivers a walk-away solution suitable for high-throughput long-read sequencing in under two hours

13 Mar 2024
Will Thompson
Editorial Assistant

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SPT Labtech, a global leader in the design, development and manufacture of automated instrumentation and consumables for life science applications, and RevoluGen Ltd. (RevoluGen), a UK genomics company, have announced the automation of RevoluGen’s Fire Monkey™ High Molecular Weight (HMW) DNA extraction chemistry in a bead-based format using SPT Labtech’s firefly® automated liquid handling platform.

The automated protocol enables the processing of up to 96 samples in parallel to prepare HMW DNA suitable for library preparation for long-read sequencing in under two hours.

The results from this collaboration, which was established in 2023, represent a meaningful advance in sample preparation efficiency for long-read DNA sequencing and eliminates the need for highly repetitive, manual pipetting. Automating liquid handling steps with firefly not only increases the speed and throughput of extraction workflows by removing productivity bottlenecks, but also improves the accuracy and repeatability of results by minimizing the risk of human error.

To achieve this, RevoluGen has applied its Fire Monkey High Molecular Weight DNA extraction chemistry to develop a magnetic bead-based DNA extraction method that is compatible with the liquid handling volumes and broad capabilities of SPT Labtech’s firefly automated liquid handling instrument.

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