Product News: Life Technologies Launches a Risk Stratification Test for Early Stage Lung CancerLife Technologies Corporation has announced the launch of Pervenio™ Lung RS. The ‘first-of-its-kind’ molecular test has been documented to reliably identify early stage lung cancer patients who are at high risk for mortality following surgery. It also fulfills an unmet need for prognostic information to guide preventative treatment and improve disease management.
Lung cancer patients face a 25-65 percent mortality rate even after successful surgery, primarily because the disease often spreads early. Current methods for lung cancer staging are not effective for identifying those patients who likely harbor undetected metastasis. By comparison, patients with colon or breast cancer, for example, can expect surgical cure rates of greater than 90 percent.
"Many lung cancer patients who are initially diagnosed with early stage disease are dying from recurrences without having received any early post-operative intervention," said Michael Mann, M.D., associate professor of cardiothoracic surgery at the University of California, San Francisco, who co-developed the test with David Jablons, M.D., chief of general thoracic surgery at the University of California, San Francisco.
"Published guidelines already urge doctors to identify early stage patients at high risk of death, so that early chemotherapy can be used to reduce that risk and save lives," said Dr. Mann. "Pervenio Lung RS has been documented to better identify the earliest stage, high-risk patients than the criteria currently suggested by these guidelines."
Developed by Pinpoint Genomics, which Life Technologies acquired in July, and based on technology licensed from the University of California, San Francisco, Pervenio™ Lung RS consists of a quantitative PCR (polymerase chain reaction) assay measuring expression of a proprietary 14-gene panel using formalin-fixed, paraffin-embedded tumor specimens. The prognostic genes are related to known molecular lung cancer pathways, such as KRAS, BRAF, EGFR, HER2,ALK, and p53.
Life Technologies' CLIA laboratory, obtained through the acquisition of Navigenics in July, is licensed in all 50 states and has currently validated the test in most states.
To order Pervenio™ Lung RS, call the Life Technologies Clinical Services Lab at 1-888-734-8588.