Agilent's new 6460 Triple Quadrupole LC/MS uses innovative Agilent Jet Stream technology to deliver best-in-class performance of any available triple quad.

07 Oct 2008
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Agilent’s new 6460 Triple Quadrupole LC/MS uses innovative Agilent Jet Stream technology to deliver best-in-class performance of any available triple quad. With proprietary Agilent Jet Stream thermal gradient focusing, improves detection limits by more than six-fold, breaking the femtogram barrier for many compounds. The system provides maximum sensitivity for the analysis of pharmaceutical compounds, trace-level environmental or food contaminants, metabolites, and biomarkers.

Agilent Jet Stream technology. Super-heated nitrogen sheath gas surrounds the nebulizer spray, increasing desolvation efficiency. More ions and fewer solvent droplets enter the sampling capillary, resulting in stronger signals with lower RSDs at the limit of detection.

Along with Agilent Jet Stream focusing, additional ion optics and vacuum system innovations help to achieve breakthrough triple quad performance in the 6460 system.

• Femtogram sensitivity—regardless of application. Maximized ion generation and transmission across a broad mass range ensure low limits of detection and quantitation for the widest range of sample types.

• Fast, sensitive MRMs. An innovative collision cell design avoids experimental cross-talk and memory effects even at very short dwell times, enabling the analysis of large multi-analyte panels, such as pesticides in food or targeted protein quantitation.

• Extended linear dynamic range ensures more reliable, more robust assays.

• Automated method development and optimization. Agilent MassHunter Optimizer Software automatically finds optimal transitions and determines fragmentor and collision energies, and selects the best possible conditions to maximize sensitivity for each compound.

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