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7 Essential Clinical Application Downloads

SelectScience

Discover the most downloaded application articles this month

8 Sept 2016
Sonia Nicholas
Managing Editor and Clinical Lead

Editorial article

Read the latest application notes, scientific posters, white papers and case studies on SelectScience®

Our clinical application article library contains a wide range of the most recent application notes, scientific posters, white papers and case studies. This article highlights seven of our most popular downloaded articles over the last month.

1. Human Blood Lymphocyte Subset Analysis with Lyse/no-wash Method

Blood is comprised of complex populations of lymphocyte, monocyte, granulocyte, platelet and red blood cells. Flow cytometry represents the best method for studying functional and phenotypic properties of these sub-populations. This application note demonstrates the use of the NovoCyte flow cytometer for the analysis of human blood lymphocyte subset.

2. SARSTEDT AG & Co. - Tips and Techniques for Preanalytics

Blood collection procedures and conditions must be standardized to ensure correct laboratory results. This guide is intended to improve collection techniques to reduce preanalytical influences. In this document, tips and technique guidance is provided for urine collection and venous and capillary blood collection.

3. A Universal Surface Coating for Lab-On-A-Chip and Biosensor Applications

Attaching biomolecules onto solid supports is a necessary step in developing and manufacturing most in vitro diagnostics and point-of care products. However, direct immobilization of antibodies to synthetic surfaces can damage proteins and adversely impact both their structure and function. This poster describes an alternative to traditional methods of biomolecule attachment that utilizes a metal polymer surface chemistry.

4. The Importance of Third Parties in Quality Control

This application note demonstrates the importance of using third parties controls that haven't been designed or optimized for use with a specific test or system. As such, they mirror the performance of patient samples providing an unbiased, independent assessment of analytical performance.

5. Lean Lab Chooses Beckman Coulter’s Power Express: Driving Peak Performance

This case study explains why the Community Regional Medical Center in the US chose the Beckman Coulter Power Express automation solution to aid their laboratory, optimizing and reducing time spent on pre-analytical processes.

6. Improving the Detection Limits of Thyroglobulin in Human Plasma by Combining Siscapa Enrichment and Microflow LC/MS

Thyroglobulin is a 660 kDa dimeric protein used as a biomarker for evaluating treatment efficiency in thyroid cancer. Current immunoassays yield high false negative rates due to the presence of auto Tg antibodies, blocking the assay in a significant portion of the patient population. This scientific poster describes an alternative approach by combining SISCAPA with standard flow LC/MS.

7. Prospective Application of the Luminex xTAG® GPP Multiplex PCR in Diagnosing Infectious Gastroenteritis

Identification of enteric pathogens currently incorporates a range of different methods with varying sensitivities, specificities, and turn-around times. In this application note, the clinical performance of the xTAG® Gastrointestinal Pathogen Panel (xTAG® GPP), a new qualitative bead-based multiplexed molecular diagnostic test, is established.

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Blood TransfusionBlood Transfusion involves giving donor blood to a recipient patient. Screening is essential to avoid transfusion reactions. Blood banks use immunohematological techniques to determine rh and ABO blood group, and screen for antibodies using specific antisera. Blood Banks use Direct Coombs Tests (DCT) and Indirect Coombs Tests (IAT) to detect hemolysis and Haemolytic Disease of the Newborn (HDN).HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Clinical MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical NGSNext Generation Sequencing (NGS) refers to the use of massive parallel sequencing of multiple small fragments of DNA. This high-throughput genomic analysis yields enormous amounts of sequence data, which if appropriately analyzed could have huge potential for clinical laboratories. For this to happen there are technique and bioinformatic hurdles to be overcome.Clinical AutomationClinical laboratory automation refers to the use of automated systems in clinical laboratories to increase efficiency, reduce human error, and improve patient care. From sample analysis to total laboratory automation, this plays a critical role in modern diagnostics and laboratory workflows. Explore clinical automation solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Clinical Mass SpectrometryMass spectrometry is emerging as a superior method of analysis over the longstanding, gold standard of immunoassay. Clinical mass spectrometry systems are increasingly accessible to medical laboratories and are capable of providing results with more speed and less expense than traditional methods. From simple mass spectrometers to IVDR class A compliant, highly sophisticated systems performing liquid chromatography tandem mass spectrometry (LC/MS/MS), find the latest product news, reviews and resources to make a purchasing decision for your laboratory. Molecular DiagnosticsMolecular diagnostics use an individual’s genetic code and gene expression to diagnose and monitor diseases. The technique is used increasingly in the field of infectious diseases and oncology, as well as areas such as coagulation, HLA typing and pharmacogenomics. Molecular diagnostics plays a pivotal role in personalized medicine.Infectious DiseasesInfectious diseases are caused by pathogens such as bacteria, viruses, and fungi. Effective detection, prevention, and treatment are crucial to control outbreaks and improve public health. Diagnostic tools, vaccines, and antimicrobial treatments are essential components of managing these diseases. Research into emerging pathogens and resistance patterns continues to evolve. Browse our peer-reviewed product directory to find the best diagnostic tools, prevention solutions, and treatment options; compare products, read customer reviews, and get pricing directly from manufacturers.

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