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Free SelectScience Webinar: Discover New Strategies for the Separation and Characterization of Protein Biopharmaceuticals

SelectScience
8 Jan 2015
Sarah Thomas
Associate Editor

Expert insights

Register for this free SelectScience webinar on January 28, 2015 to learn about advances in the techniques and methods being used to investigate biopharmaceuticals.

Protein biopharmaceuticals are being developed at an explosive rate and have attracted great interest from both smaller biotech firms and big pharma. Developing protein biopharmaceuticals and their follow-on versions is highly demanding in many ways. From an analytical perspective, handling biomolecules presents new challenges for chromatographers, and the field of bio-chromatography is advancing rapidly as new and higher resolution techniques for characterizing proteins, including monoclonal antibodies, are evaluated and better understood.

In this webinar, Koen Sandra, PhD, of the Research Institute for Chromatography, will discuss his team’s recent analytical work to evaluate both innovator biopharmaceuticals and biosimilars. The multiple UHPLC and LC/MS techniques used and the rationale for the selection of the different techniques and methods will be highlighted. Maureen Joseph, PhD, of Agilent Technologies, will also join the webinar to share some highlights of new bio-column technologies that support the techniques used.

This one-hour webinar will take place twice on Wednesday January 28 at the times below, giving you the option to attend the session that best fits with your schedule.

05:00 PST / 08:00 EST / 13:00 GMT / 14:00 CET
OR
11:00 PST / 14:00 EST / 19:00 GMT / 20:00 CET

Register here to save your space.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.BiosimilarsBiosimilars are very similar versions of approved and authorized medicines. Clinically inactive components will have minor differences, but there are no significant differences between the biosimilar and the original product in terms of potency, purity and safety.

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Free SelectScience Webinar: Discover New Strategies for the Separation and Characterization of Protein Biopharmaceuticals