3D Cell Culture: An Early-Stage Oncology Drug Discovery Tool
31 Jan 2013New testing methods are imperative at early stages of drug development to reduce the expensive, late-stage failures due to efficacy and safety. Drug testing data, particularly in oncology, from in vivo-mimicking 3D cell cultures have the potential to play a pivotal role in early-stage decision-making about the probability of therapeutic candidates’ success. This white paper demonstrates the capabilities of the Perfecta3D Hanging Drop Plates from 3D Biomatrix for spheroid growth and subsequent high-throughput testing of anti-cancer compounds at the preclinical discovery phase.
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Perfecta3D Hanging Drop Plates - 384-Well
3D BiomatrixThe patent-pending Perfecta3D® Hanging Drop Plates are 96- and 384-well plates that facilitate the formation, culture, and testing of three-dimensional (3D) spheroids and stem cell aggregates without the aid of coatings or matrices. With only one spheroid forming in each well, 3D spheroids formed in Perfecta3D Hanging Drop Plates are consistent and diameter can be controlled by the number of cells seeded in each well. Media and compounds can be added or removed from the top of the plate, and cells can be added for patterned co-cultures. The well plate format means that the plates are compatible with manual or automated liquid handling equipment. Product and ordering information can be found at www.3DBiomatrix.com/products.
Perfecta3D Hanging Drop Plates - 96-Well
3D BiomatrixThe patent-pending Perfecta3D® Hanging Drop Plates are 96- and 384-well plates that facilitate the formation, culture, and testing of three-dimensional (3D) spheroids and stem cell aggregates without the aid of coatings or matrices. With only one spheroid forming in each well, 3D spheroids formed in Perfecta3D Hanging Drop Plates are consistent and diameter can be controlled by the number of cells seeded in each well. Media and compounds can be added or removed from the top of the plate, and cells can be added for patterned co-cultures. The well plate format means that the plates are compatible with manual or automated liquid handling equipment. Product and ordering information can be found at www.3DBiomatrix.com/products.