Ultrafast Analysis of Metabolic Stability Assays Using Agilent RapidFire High-resolution MS>

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Ultrafast Analysis of Metabolic Stability Assays Using Agilent RapidFire High-resolution MS
13 Feb 2012

The analysis of in vitro ADME assays like metabolic stability is often a throughput bottleneck in the drug discovery process. Assay results generated by LC/MS/MS were compared to those of the Agilent RapidFire 360 High-throughput Mass Spectrometry System integrated with a high resolution accurate mass Q-TOF MS. The two systems provided equivalent assay results, but the Agilent RapidFire 360
offered a more efﬁcient workﬂow and higher throughput.