Ultrafast Analysis of Gabapentin and Pregabalin in Urine Using the Agilent RapidFire High-Throughput Mass Spectrometry System
5 Aug 2014
The measurement of gabapentin and pregabalin in urine requires a reliable, efficient, and accurate method. We developed an analytical method using a SPE/MS/MS system to measure these analytes in urine with much faster sample cycle times, and similar analytical results compared to traditional methods. A simple dilute-and-shoot based analysis by the Agilent RapidFire/MS/MS permits accurate and precise measurement of these analytes over a linear range of 0.5 to 100 mcg/mL. Samples were analyzed at 25 seconds per sample, providing a much higher throughput method of analysis compared to traditional protocols.