Determine Aggregation Propensity with ΔG Trend and the HUNK
30 September 2016

This application note describes how the HUNK can be used to determine G (the Gibbs free energy of protein unfolding) measurements. The HUNK is a fully automated platform for chemical denaturation which provides and rapid and early predictive assessment of protein stability. This allows you to develop a protein construct with the lowest propensity to aggregate.  The HUNK is easy to use and once the results have been obtained data analysis can be performed by the HUNK software or exported.