Quantitative Analysis of APIs in Blending Mixtures and Tablets
13 Aug 2014

This application note demonstrates that Raman spectroscopy with chemometrics can be used to develop a quantitative method to measure the concentration of APIs such as Naltrexone HCl in blending mixtures and final product tablets. The method provides quick predictions of API concentrations in blending mixtures, allowing for use in the on-line monitoring for blending processes. The high sensitivity, high resolution, and stability of the i-Raman Plus instrument conform to the requirements in developing reliable quantitative Raman analysis methods.

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