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Integral to molecular diagnostic operations is the generation of high quality plasma from whole blood samples. The Vivid Plasma Separation membrane utilizes a patented process where a highly asymmetric membrane is specifically engineered for the generation of plasma from whole blood. The highly asymmetric nature of the membrane allows the cellular components of the blood (red cells, white cells, and platelets) to be captured in the larger pores without lysis, while the plasma flows down into the smaller pores on the downstream side of the membrane. The rapid separation process yields plasma similar in HPLC and SDS PAGE profiles to traditional centrifuged plasma in less than two minutes.