Ultrafiltration and Microfiltration TFF Cassette Membranes

Ultrafiltration and Microfiltration TFF Cassette Membranes

Pall Life Sciences Products - Biopharmaceutical Division

Pall’s ultrafiltration (UF) membranes have been developed and manufactured to give consistent performance. Products are available for laboratory, development, pilot, and production-scale TFF applicati...read more

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Pall’s ultrafiltration (UF) membranes have been developed and manufactured to give consistent performance. Products are available for laboratory, development, pilot, and production-scale TFF applications. Pall’s microfiltration (MF) membranes are optimized for product clarification and recovery in biotechnology and pharmaceutical applications.

Membrane Types
Pall offers four distinct membrane types that provide superior performance and stability to meet the challenges of each unique TFF application. Membrane Types include: Omega™, Alpha™, Regen™, and Supor® TFF membranes. Each membrane is available in a broad range of cassette types and configurations.

Omega Membrane
Omega polyethersulfone (PES) membranes have been specifically modified to minimize protein binding to the surface and interstitial structure of the membrane. This polymeric membrane is stable against biological and physical degradation due to the unique chemical properties of PES.
Omega membranes have an anisotropic structure, a thin skin-like top layer with a highly porous underlying support. The structure of the skin determines the porosity and permeability characteristics of the membrane. Anisotropic membranes have higher water permeability and can typically be cleaned quicker and easier than membranes with a uniform, sub-micron depth structure.
Damage to the skin of anisotropic membranes is easily detected with an integrity test. This may not be the case for membranes with sub-micron porous underlayers.

Features and Benefits
• Low affinity and adsorption characteristics resulting in higher product recovery
• Available in a wide variety of cassette configurations, for easy and direct scale-up/scale down
• Greatest selection of ultrafiltration membrane rating available: 650 Da – 1000 kDa to fit specific application needs
• Compatible with acids, bases and a variety of other cleaning agents to optimize for example cleaning procedures

Alpha Membrane
Alpha membrane is a PES membrane modified to minimize the flux depression caused by antifoam agents (such as silicone and polyglycols) that might effect especially membranes with smaller cut offs. Alpha membranes typically clean up quicker and easier after contact with these agents.

Features and Benefits
• Proprietary membrane chemistry reduces non-specific adsorption, minimizes membrane fouling and increases product recovery
• Exceptional membrane recovery and stability after cleaning which results in a longer lifetime of the membrane

Regen Membrane
Regen membrane is regenerated cellulose. This hydrophilic membrane is characterized as low protein binding with a broad chemical compatibility. Regenerated cellulose membranes have lower water permeability compared to PES membranes but may give higher, consistent process flux rates especially if antifoam agents or polysaccharides are present in the process fluid.

Features and Benefits
• Good for processing hydrophobic proteins where the low binding characteristic increases the performance of the membrane
• Maintains high process flux rates in presence of antifoams and polysaccharides which can lead to shorter process time
• Broad solvent compatibility to handle also applications where PES membranes can not be used
May be substituted where regenerated cellulose is specified and validated to minimize the effort of revalidation

Supor TFF Membrane
Supor TFF membrane is a micron-rated pore, modified polyethersulphone membrane with a uniform depth structure. The membrane is optimized for microfiltration TFF applications including harvest, concentration and clarification of cell cultures and fermentation broths. Use Supor TFF membranes to harvest bacterial, mammalian, and insect cells; separate red blood cells from hemoglobin; and clarify yeast broth and bacterial lysates.

Features and Benefits
• Low non-specific adsorption due to its hydrophilic chemistry which leads to higher product yields
• Wide range of membrane pore sizes to optimize the process
• Compatible with acids, bases, oxidizing agents and variety of other cleaning agents to fit different application needs


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