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Advanced ReviewerMembership Status
Member since: 2015
Organization: EMD Serono
Application Area: Kinetic profiling
"The ADP2 assay is a great choice for measuring activity for any ADP-generating enzyme in both real time and endpoint formats. The universal detection system has been very useful for more challenging targets in our lab."
Member since: 2007
Organization: Eli Lilly Co
"Excellent blend of simplicity, economics & good science. Excellent technical support."
To accommodate the variety of instrument and detection format preferences expressed by BellBrook lab customers, BellBrook Labs have expanded the Transcreener ADP2 Assay product line to include three fluorescent detection formats, all with emission in the red region of the visible spectrum to minimize compound interference. All three assays share the same qualities of assay sensitivity and ease of use. Whether you are doing assay development, screening, or hit to lead activities, there is a Transcreener ADP2 Assay that is right for you
Features of BellBrook Labs Transcreener ADP2 Assay:
• New EZ Protocol
• Increased Sensitivity
• Use Less Enzyme
• Screen Low Specific Activity Enzymes
• Excellent Z' Values at Initial Enzyme Velocity Kinetics
• Miniaturize to 1536
• Robust Performance on Industry-Standard Microplate Readers
The Bell Brook Labs Transcreener ADP2 FP Assay is a new assay, with greater sensitivity than the original BellBrook Lab Transcreener ADP Assay. The improvement is a more sensitive antibody against ADP yielding an excellent signal at less than or equal to 10% ATP consumption for a broad range of initial ATP concentrations (0.1-1,000 μM). The result is the ability to screen low ATP Km enzymes, and to use initial velocity enzyme kinetics at or below ATP Km concentrations, which leads to accurate inhibitor potencies and the ability to use less enzyme and substrate. Ratiometric, red-shifted fluorescence polarization output minimizes signal variability and reduces compound interference, resulting in robust Z´ values ≥ 0.7 in 384 and 1536-well formats.