RNA Phosphoramidites

Phosphoramidites for RNA oligonucleotides synthesis and more.Features of RNA Phosphoramidites: Amine groups are protected by “either a benzoyl or isobutyryl group {dA(Bz), dC(Bz), dG(Ib)}. Cleavage and deprotection procedures for RNA synthesis is similar to DNA synthesis, with just an additional step to remove the 2'-OH protecting group. The 2'-OH group is protected by a tert-butyldimethylsilyl (TBDMS) group to prevent derivatization and degradation during the synthesis cycle. Standard RNA amidites provide excellent coupling efficiency when used together with either ETT or BTT as an activator. The purities of manufactured nucleoside phosphoramidites are quality control-checked by RP HPLC/31P-NMR analysis. (RP- HPLC: ≥ 97%, 31P-NMR: ≥ 98%) Technical Information for RNA Phosphorami...Read more

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Description

Phosphoramidites for RNA oligonucleotides synthesis and more.

Features of RNA Phosphoramidites:

  • Amine groups are protected by “either a benzoyl or isobutyryl group {dA(Bz), dC(Bz), dG(Ib)}.
  • Cleavage and deprotection procedures for RNA synthesis is similar to DNA synthesis, with just an additional step to remove the 2'-OH protecting group.
  • The 2'-OH group is protected by a tert-butyldimethylsilyl (TBDMS) group to prevent derivatization and degradation during the synthesis cycle.
  • Standard RNA amidites provide excellent coupling efficiency when used together with either ETT or BTT as an activator.
  • The purities of manufactured nucleoside phosphoramidites are quality control-checked by RP HPLC/31P-NMR analysis. (RP- HPLC: ≥ 97%, 31P-NMR: ≥ 98%)

Technical Information for RNA Phosphoramidites:

  • rA(Bz)-CE phosphoramidite
  • rC(Bz)-CE phosphoramidite
  • rG(Ib)-CE phosphoramidite
  • rU-CE phosphoramidite

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