Raptor™ Biphenyl LC Column by Restek Corp.

Manufacturer Restek Corp.
  |  3 reviews

Raptor™ Biphenyl LC Column by Restek Corp. product image
Raptor™ Biphenyl LC Column
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Average Rating: 4.6
3 Scientists have reviewed this product

5 out of 5
Ease of use
4 out of 5
After sales service
5 out of 5
Value for money

Efficient column for use in SFC
Rating: 5.0

  • Application Area: Multiple applications by SFE-SFC

"We are currently building a repertoire of columns to use in SFC for multiple applications. We've had some success with separating PAH & metabolites using the 150 mm x 4.6 mm x 2.7 u Raptor Biphenyl column, as well as fat soluble vitamins. This column allows us to operate at high flow rates for fast separations. Excellent customer service!"

Review date: 23 Mar 2017 | Raptor™ Biphenyl LC Column
  • Status:


  • Member since: 2015

  • Organization: Department of Forensic Science, Laurentian University

  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
As promised, this column does a better job of resolving our analytes from matrix constituents than the traditional C18 chemistry we were using.
Rating: 4.7

  • Application Area:Analysis of post-mortem tissues for drugs and metabolites

"As promised, this column does a better job of resolving our analytes (antipsychotic drugs) from matrix constituents (post-mortem - decomposed - bone tissue extracts) than the traditional C18 chemistry we were using. We are using PDA detection, where chromatographic resolution is much more critical than with MS detection. As a result we are using the 150 mm x 2.1 mm column (1.7 um) particle size."

Review date: 22 Jun 2015 | Raptor™ Biphenyl LC Column
  • Status:

    Advanced Reviewer

  • Member since: 2010

  • Organization: Ernest Jackson

  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Rating: 4.0

  • Application Area:HPLC Analysis Of Pharmaceuticals

"This offers an interesting alternative to C18 and complex mobile phases for some difficult separations. It appears to have advantages over phenyl-hexyl, and with more experience, I may use the Raptor as my generic phase of first choice. It has good efficiency, allowing the possibility of shorter run times. It is well worth investigating for troublesome applications."

Review date: 27 Jan 2014 | Raptor™ Biphenyl LC Column
With Raptor™ LC columns, Restek chemists became the first to combine the speed of superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC® technology. This new breed of chromatographic column allows you to more easily achieve peak separation and faster analysis times without expensive UHPLC instrumentation.

SPP core-shell columns commonly employ traditional phenyl-hexyl stationary phases, but the innovative Biphenyl ligand, developed by Restek’s chemists, is the next generation of phenyl column chemistry. It provides greater aromatic selectivity than commercially available phenyl-hexyl columns[1] and a greater degree of dispersion than conventional phenyls. As a result, the Raptor™ Biphenyl allows you to more easily separate bioanalytical compounds like aromatics, which elute early or are hard to separate on C18 or other phenyl chemistries.

One of the greatest advantages of an SPP column is the ability to achieve fast, efficient separations by operating at higher linear velocities than are possible with a convbentiaonal fully porous particle column. However this can also result in higher back pressures. Raptor™ columns were designed to handle the increased pressures needed to achieve Selectively Accelerated, and handle it far better than other SPP columns on the market.

Raptor™ Biphenyl LC Column Features & Benefits:

  • Higher efficiency for drastically faster analysis times.
  • Better selectivity for substantially improved resolution.
  • Increased sample throughput with existing HPLC instrumentation.
  • Ideal for bioanalytical testing applications like drug and metabolite analyses.
  • Heightened selectivity and retention for compounds that are hard to resolve or elute early on C18 and other phenyl chemistries.
  • Limits ionization suppression and allows simple, MS-friendly mobile phases.
  • Restek's most popular LC stationary phase applied to Raptor™ SPP core-shell silica.

Column Details:

  • Stationary Phase Category: Phenyl (L11)
  • Ligand Type: Biphenyl
  • Particle: 2.7um SPP
  • Pore Size: 90 Å
  • Surface Area: 150 m2/g
  • Length: 30 - 150 mm
  • ID: 2.1, 3.0, 4.6 mm