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Member since: 2015
Organization: Department of Forensic Science, Laurentian University
As promised, this column does a better job of resolving our analytes from matrix constituents than the traditional C18 chemistry we were using.
Application Area: Analysis of post-mortem tissues for drugs and metabolites
"As promised, this column does a better job of resolving our analytes (antipsychotic drugs) from matrix constituents (post-mortem - decomposed - bone tissue extracts) than the traditional C18 chemistry we were using. We are using PDA detection, where chromatographic resolution is much more critical than with MS detection. As a result we are using the 150 mm x 2.1 mm column (1.7 um) particle size."
Member since: 2010
Organization: Ernest Jackson
Application Area:HPLC Analysis Of Pharmaceuticals
"This offers an interesting alternative to C18 and complex mobile phases for some difficult separations. It appears to have advantages over phenyl-hexyl, and with more experience, I may use the Raptor as my generic phase of first choice. It has good efficiency, allowing the possibility of shorter run times. It is well worth investigating for troublesome applications."
SPP core-shell columns commonly employ traditional phenyl-hexyl stationary phases, but the innovative Biphenyl ligand, developed by Restek’s chemists, is the next generation of phenyl column chemistry. It provides greater aromatic selectivity than commercially available phenyl-hexyl columns and a greater degree of dispersion than conventional phenyls. As a result, the Raptor™ Biphenyl allows you to more easily separate bioanalytical compounds like aromatics, which elute early or are hard to separate on C18 or other phenyl chemistries.
One of the greatest advantages of an SPP column is the ability to achieve fast, efficient separations by operating at higher linear velocities than are possible with a convbentiaonal fully porous particle column. However this can also result in higher back pressures. Raptor™ columns were designed to handle the increased pressures needed to achieve Selectively Accelerated, and handle it far better than other SPP columns on the market.
Raptor™ Biphenyl LC Column Features & Benefits: