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OPTI-LYNX™ Quick Connect Guard Columns

Optimize Technologies, Inc.

The OPTI-LYNX™ QuickConnect Guard Column is a high-performance, cartridge-based guard system, suitable for use with any 10-32 analytical column due to its auto-adjusting ZDV port adapter. OPTI-LYNX™ combines effective column protection with the convenience of quick-connect operation. Some cartridge-based guard column products offer convenience with a price: higher internal volumes. Optimize Technologies, refuse to compromise p…

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The OPTI-LYNX™ QuickConnect Guard Column is a high-performance, cartridge-based guard system, suitable for use with any 10-32 analytical column due to its auto-adjusting ZDV port adapter. OPTI-LYNX™ combines effective column protection with the convenience of quick-connect operation. Some cartridge-based guard column products offer convenience with a price: higher internal volumes. Optimize Technologies, refuse to compromise performance for anything. OPTI-LYNX™ utilizes low dispersion component interfaces to keep extra column volume to a minimum: connection paths have a total internal volume of less than 2µL. You get quick-connect convenience and low dispersion, all in one package.

Application NoteSeparations

Optimize trapping guide

Trapping is a valuable technique for sample clean-up, purification, pre-concentration, desalting, and detergent removal. This comprehensive guide to trapping from Optimize Technologies, aims to help you select the best options for your LC and LC/MS applications.

2 Oct 2025

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OPTI-LYNX™ Quick Connect Guard Columns - Optimize Technologies, Inc. - Separations

OPTI-LYNX™ Quick Connect Guard Columns

Optimize Technologies, Inc.

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EXP® Hand-Tight Nut & Titanium Hybrid Ferrule
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The EXP® Hand-Tight Nut & Titanium Hybrid Ferrule fitting system is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the swage can be released without tools to adjust to the different port depths on various pieces of hardware. This adjustability provides unlimited value through repeated zero-dead-volume connections with any 10-32 port. With the EXP® Fitting System, you no longer have to clip off and replace swaged ferrules or wonder if you are achieving the best possible connection. Key Features:Hand-Tight - rated to 20,000+ psi (1,400+ bar)Tested to 30,000 psiAuto-adjusting ZDV ConnectionIntended for many repeat usesNo more cut-off and replacement of swaged ferrulesSimple and versatile - can be used in UHPLC and HPLC applicationsPacks include 10-20-00273 and 15-24-03831
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EXP® Pre-Column Filters
Optimize Technologies, Inc.
The EXP® Pre-Column Filter is ideal for protecting small-particle UHPLC columns at extreme pressures. Such techniques analyze samples in the most demanding applications, which can decrease the life of these expensive columns. EXP® Pre-Column Filters help extend that life and protect your column investment without sacrificing performance. Free-Turn® architecture allows the user to change cartridges by hand without breaking fluid connections on the holder inlet/outlet. EXP® Pre-Column Filter holders are available with Titanium Hybrid ferrules for easy direct connection to any 10-32 port. The filter holder comes as a complete package including fittings to provide repeated zero-dead volume column connections.Key Features:Approved for use at 20,000+ psi (1,400+ bar)Hand-tight filter replacement - no tools required!Depth filtration maximizes capacityAuto-adjusting ZDV column connectionCustom volumes/ porosities availableLow-volume/ low-dispersion cartridgeHardened stainless steel end cap eliminates gallingFeatures Free-Turn® architectureFittings included
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EXP® Titanium Hybrid Ferrule
Optimize Technologies, Inc.
The EXP® Fitting System is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the swage can be released without tools to adjust to the different port depths of various hardware. This adjustability provides unlimited value through repeated zero-dead-volume connections with any 10-32 port. With the EXP® Fitting System, you no longer have to clip off and replace swaged ferrules or wonder if you are achieving the best possible connection. The EXP® ferrule, with its innovative capabilities, forms the foundation of our EXP® product family. Key Features:Rated to 20,000+ psi (1,400+ bar)Tested to 30,000 psiAuto-adjusting ZDV ConnectionIntended for many repeat usesNo more cut-off and replacement of swaged ferrulesSimple and versatile - can be used in UHPLC and HPLC applicationsUse with EXP® Nuts and Holders
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EXP® Hex Head Nut & Titanium Hybrid Ferrule
Optimize Technologies, Inc.
The EXP® Hex Head Nut & Titanium Hybrid Ferrule fitting system is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the swage can be released without tools to adjust to the different port depths of various hardware. This adjustability provides unlimited value through repeated zero-dead-volume connections with any 10-32 port. With the EXP® Fitting System, you no longer have to clip off and replace swaged ferrules or wonder if you are achieving the best possible connection.Key Features:Wrench-Tight, Rated to 20,000+ psi (1,400+ bar)Tested to 30,000 psiAuto-adjusting ZDV ConnectionNo longer have to clip off and replace swaged ferrulesIntended for many repeat usesSimple and versatile - can be used in UHPLC and HPLC applications
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EXP® Guard Column Cartridge
Optimize Technologies, Inc.
The EXP® Guard Column cartridge system is rated to 15,000 psi with hand-tight replaceable cartridges. This unique design connects directly to any UHPLC column with the auto-adjusting Titanium Hybrid Ferrule and EXP® Fittings, providing repeated zero-dead-volume connections and easy adjustability between various column types. Free-Turn¨ architecture allows the user to change cartridges by hand without breaking fluid connections on the holder inlet/ outlet. The combination of low-dispersion and ultra high-pressure capabilities provides effective protection with negligible effects on retention time, plate count, and peak shape. Key Features:Hand-tight cartridge replacement - NO TOOLS!Hardware rated to 20,000+ psi (1,400+ bar)1.4µL Swept Volume (excluding packed bed)Auto-adjusting ZDV column connectionHardened stainless steel end cap eliminates gallingFeatures Free-Turn® architectureHolder can be used with EXP® Trap and Guard CartridgesFittings included with holder
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EXP® Trap Columns
Optimize Technologies, Inc.
The patent-pending EXP® Trap Column is rated for use at 20,000+ psi (1,400+ bar). This unique design connects directly to any injection valve (with 10-32 threads) or in-line with 1/16” stainless tubing for unparalleled convenience and efficiency. The EXP® Cartridge System enables chemists to quickly remove detergents or salts which can affect the ionization process in MS work. This trapping technique can concentrate the sample directly on-line, allowing for increased recovery of precious sample material compared to off-line techniques. On-line trapping readily lends itself to automation for high-throughput analysis in UHPLC/MS applications. Free-Turn® architecture allows the user to change cartridges by hand without breaking fluid connections on the holder inlet/outlet.Key Features:Includes 3 uni-directional cartridgesRated to 20,000+ psi (1,400+ bar)Bed volumes from 4 µL to 100 µLConvenient means of handling a variety of sample clean-up and enrichment processesMore efficient than off-line trapping techniquesHand-tight trap replacement - NO TOOLS!Custom packing availableHolder can be used with EXP® Trap and Guard CartridgesFittings included with holder
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OPTI-MAX® Check Valves and Cartridges
Optimize Technologies, Inc.
OPTI-MAX® Cartridge Check Valves are designed to offer maximum performance and ease of use. From the sharp, consistent threads on OPTI-MAX® custom housings, to the exacting standards used to match ball/seat sets in OPTI-MAX® cartridges, every aspect of design and manufacturing reflects an unavoidable fact: when it comes to reliable check valve operation, quality and precision make a big difference. OPTI-MAX® check valves offer many advantages over OEM check valve systems, and are better designed, better made and more reliable than any other after-market check valve product. Additionally, OPTI-MAX® Free-Turn® housings can be removed with the tubing still attached, accelerating check valve maintenance while reducing fitting wear.Each ball and seat set is individually matched to ensure a lock-and-key fit. This guarantees 3 bubbles/minute or less in the industry standard nitrogen bubble test; common acceptable standards are 12 bubbles or less. We have also minimized the ball travel distance within the check valve; less travel distance equals quicker seating and more accurate pump metering. Simply put, tighter specifications make a better valve. A single OPTI-MAX® cartridge is interchangeable across multiple pump brands, and will function in either the inlet or outlet position. The same replacement cartridge will fit into OPTI-MAX® housings for pumps made by Waters, Shimadzu, Agilent/HP, and most other OEM solvent delivery systems. This allows you to minimize the number of spare check valve cartridges you keep on hand, and dramatically reduce the cost of inventory required to cover your maintenance needs.
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EXP® Stem Trap
Optimize Technologies, Inc.
The entire EXP® Stem Trap and reusable holder are only slightly larger than a standard HPLC fitting. Its slim architecture allows it to easily fit into crowded instrument compartments or to connect directly to tightly-spaced injection ports. When tightened by hand, the EXP® Stem Trap seals to 8,700+ psi. All configurations incorporate wrench-flats to enable flawless sealing to 20,000+ psi (1,400+ bar). The unique packed floating stem installs directly into any 10-32 port and automatically adjusts to provide a perfect ZDV connection. The EXP® System enables chemists to quickly remove detergents or salts which can affect the ionization process in MS work. This trapping technique can concentrate the sample directly on-line, allowing for increased recovery of precious sample material compared to off-line techniques. On-line trapping readily lends itself to automation for high-throughput analysis in UHPLC/MS applications. Key Features:Kit includes EXP® Stem Holder with fittings and 3 EXP® Stem TrapsRated to 20,000+ psi (1,400+ bar)Hand-tight and wrench-tight configurationIntended for many repeat usesAuto-adjusting ZDV connectionBed volumes from 0.17 µL to 2.6 µLLow-volume/ low-dispersion cartridgesCustom packing available
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EXP® Hand-Tight Coupler
Optimize Technologies, Inc.
The EXP® Hand Tight Coupler is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the swage can be released without tools to adjust to the different port depths of various hardware. This adjustability provides unlimited value through repeated zero-dead-volume connections with any 10-32 port. With the EXP® Fitting System, you no longer have to clip off and replace swaged ferrules or wonder if you are achieving the best possible connection.Key Features:Includes 1/16"OD x 0.005" ID SS tubing and 2 EXP® hand-tight fittingsRated to 20,000+ psi (1,400+ bar)Tested to 30,000 psiAuto-adjusting ZDV ConnectionIntended for many repeat usesNo more cut-off and replacement of swaged ferrulesSimple and versatile - can be used in UHPLC and HPLC applications
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EXP® Stem Filter
Optimize Technologies, Inc.
The EXP® Stem Filter features a choice of frit porosities integrated with our patented auto-adjusting stem for repeated ZDV connections with any 10-32 port. The entire filter stem and reusable holder are only slightly larger than a standard HPLC fitting. This slim architecture allows it to easily fit into crowded instrument compartments, tightly spaced injection ports, and anywhere else you need an extra level of protection against clogging and contamination. When tightened by hand, the EXP® Stem Filter seals to 8,700+ psi. The reusable holder hardware also incorporates wrench flats to enable flawless sealing to 20,000+ psi (1,400+ bar). The EXP® Stem Filter is the ultimate low-impact protection for expensive UHPLC and MS equipment, assuring trouble-free performance so you can concentrate on the data, not troubleshooting.Key Features:Kit includes: Stem Holder,3 Disposable Stem Filter Cartridges and fittingsApproved for use at 20,000+ psi (1,400+ bar)Hand-tight and wrench-tight configurationReusable holder intended for many repeat usesAuto-adjusting ZDV connectionsLow-dispersion cartridgesUltra-low .27 µL total swept volumeCustom volumes/ porosities available
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EXP® Hand-Tight Nut & Titanium Hybrid Nano Ferrule
Optimize Technologies, Inc.
The EXP® Hand Tight Nano Fittings System offers hand-tight and hex head adjustable nut and ferrule compression fittings for extreme pressure connections between 1/32” stainless steel tubing and 6-40 ports.Ideal for nano-scale UHPLC and UHPLC/MS, this nut and ferrule compression fitting is rated to 20,000+ psi (1400+ bar). The patent-pending EXP® 1/32” Titanium Hybrid Ferrule combines the sealing capability of PEEK and robust nature of titanium to create the perfect seal. The ferrule can be released without tools, as the titanium permits the swage to be released and reset, allowing for many repeat connections and the ability to adjust to various port depths. The EXP® product line streamlines the process of making fluid connections for UHPLC hardware and reduces instrument downtime. The combination of specialized features, innovative technology, and precision manufacturing make the EXP® Nano Fittings an unbeatable choice for chromatographers operating at both HPLC and UHPLC pressures.Key Features:Hand-TightRated to 20,000+ psi (1,400+ bar)One piece ferrule designPerfect for nano-scale UHPLC and UHPLC/MSAuto-adjusting ZDV connectionIntended for many repeat uses
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EXP® Analytical Columns
Optimize Technologies, Inc.
The cartridge-based EXP® Analytical Column System is designed for superior chromatographic analysis with each injection rated for routine use up to 20,000 psi.The new EXP® Analytical Column Holders incorporate Free-Turn® architecture allowing the user to quickly exchange columns, by hand, without breaking any fluid connections. The EXP® Analytical Column Holders are available in two formats: In-Line and Direct Connect, allowing the user to bypass additional tubing and connect directly to the detector for even greater resolution. Holder kits also include EXP® Nuts and Titanium Hybrid Ferrules to ensure repeated zero-dead-volume connections.The EXP® Analytical Column Hardware is precision machined and held to the highest of specifications to ensure excellent performance and repeatability. EXP® Analytical Column Hardware is available for purchase as empty columns. The column hardware is assembled up to the point of packing, allowing the customer to completely control the resins used, packing processes and testing conditions. Packing fixtures are also available and are compatible with all column dimensions. Key Features:Hardware rated to 20,000+ psi (1400+ bar)Hand-Tight, NO TOOLS! Cartridge-Based FormatRepeated Column PerformanceFree-Turn® architecture for quick exchanges of columnsQuick Connect/DisconnectRepeated ZDV connectionsCustom Packing Available
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EXP® Nano Trap
Optimize Technologies, Inc.
The EXP® Nano Trap System is designed to remove detergents or salts which can affect the ionization process in MS work rated for routine use up to 20,000 psi.The new nano-scale traps are available in two formats – EXP® Nano Trap and EXP® Nano Trap HR. Both formats are available in 10 or 20 mm lengths and in a variety of bed volumes ranging from 0.25µL - 4.0µL. The EXP® Nano Trap follows a traditional trap column format, designed for removing detergents or salts in an offline sample loop. The new EXP® Nano Trap HR is designed as a vented trap, with an even further reduction in extra column volume, resulting in impeccable and repeatable high-resolution Nano-LC. Concentrating the sample on-line with the EXP® Nano Trap HR promotes increased recovery of the sample when compared with off-line techniques.The brand new EXP® Nano Trap Holder incorporates Free-Turn® architecture, allowing the user to quickly exchange trap columns by hand without breaking any fluid connections. The universal holder is compatible with both column types and lengths. Nano Holder Kits include auto-adjusting EXP® Nano Fittings, 6-40 thread, to ensure repeated zero-dead-volume connections. Key Features:Rated to 20,000+ psi (1,400+ bar)Cartridge-Based FormatKits contain: 1 holder & 2 trapsReplacement traps come in 3 packsReduced Column Volume for superior performanceFree-Turn® Architecture for quick & convenient exchangesAvailable in bed volumes from 0.25µL to 4µLRepeated ZDV ConnectionsHand-tight, no tools!
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EXP® Hex-Head Nano Fitting
Optimize Technologies, Inc.
The EXP® Nano Fittings System offers hand-tight and hex head adjustable nut and ferrule compression fittings for extreme pressure connections between 1/32” stainless steel tubing and 6-40 ports.Ideal for nano-scale UHPLC and UHPLC/MS, this nut and ferrule compression fitting is rated to 20,000+ psi (1400+ bar). The patent-pending EXP® 1/32” Titanium Hybrid Ferrule combines the sealing capability of PEEK and robust nature of titanium to create the perfect seal. The ferrule can be released without tools, as the titanium permits the swage to be released and reset, allowing for many repeat connections and the ability to adjust to various port depths. The EXP® product line streamlines the process of making fluid connections for UHPLC hardware and reduces instrument downtime. The combination of specialized features, innovative technology, and precision manufacturing make the EXP® Nano Fittings an unbeatable choice for chromatographers operating at both HPLC and UHPLC pressures.Key Features:Rated to 20,000+ psi (1,400+ bar)One piece ferrule designPerfect for nano-scale UHPLC and UHPLC/MSAuto-adjusting ZDV connectionIntended for many repeat uses
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OPTI-MAX® EXP® Check Valves
Optimize Technologies, Inc.
OPTI-MAX® Cartridge Check Valves are designed to offer maximum performance and ease of use. From the sharp, consistent threads on OPTI-MAX® custom housings, to the exacting standards used to match ball/seat sets in OPTI-MAX® cartridges, every aspect of design and manufacturing reflects an unavoidable fact: when it comes to reliable check valve operation, quality and precision make a big difference. OPTI-MAX® check valves offer many advantages over OEM check valve systems, and are better designed, better made and more reliable than any other after-market check valve product. Additionally, OPTI-MAX® Free-Turn® housings can be removed with the tubing still attached, accelerating check valve maintenance while reducing fitting wear.Each ball and seat set is individually matched to ensure a lock-and-key fit. This guarantees 3 bubbles/minute or less in the industry standard nitrogen bubble test; common acceptable standards are 12 bubbles or less. We have also minimized the ball travel distance within the check valve; less travel distance equals quicker seating and more accurate pump metering. Simply put, tighter specifications make a better valve. A single OPTI-MAX® cartridge is interchangeable across multiple pump brands, and will function in either the inlet or outlet position. The same replacement cartridge will fit into OPTI-MAX® housings for pumps made by Waters, Shimadzu, Agilent/HP, and most other OEM solvent delivery systems. This allows you to minimize the number of spare check valve cartridges you keep on hand, and dramatically reduce the cost of inventory required to cover your maintenance needs. If your pump model and/or check valve housings are not listed on our website, please contact us directly as the new OPTI-MAX® EXP® product line is continually expanding.
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