Thermo Scientific™ OmniPac® PCX-500 Mixed-Mode Column by Thermo Fisher Scientific

Thermo Scientific™ OmniPac® PCX-500 Mixed-Mode Column by Thermo Fisher Scientific product image
Thermo Scientific™ OmniPac® PCX-500 Mixed-Mode Column

Thermo Fisher Scientific

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The OmniPac® PCX-500 column is a macroporous, high-capacity, solvent-compatible column designed to separate cationic and neutral species in a single run. This column combines cation-exchange and polymeric reversed-phase retention mechanisms in a single column.

The multimode separation mechanism is achieved by coating a macroporous hydrophobic core for reversed-phase retention with a cation-exchange latex bead layer for cation-exchange retention. The macroporous structure provides an accessible hydrophobic core where reversed-phase retention occurs. The cation-exchange selectivity is provided by a cation-exchange MicroBead™ layer that coats the hydrophobic core. Since the cation-exchange layer is identical to that of the OmniPac PCX-100, the two columns exhibit similar ion-exchange selectivity.

As a result, the OmniPac PXC-100 can be used to develop the ion-exchange separation, and the method can then be transferred to the OmniPac PXC-500 for further refinement to include solvent for the reversed-phase separation. The OmniPac PCX-500 is 100% solvent compatible and should always be run with at least 1% organic solvent in the mobile phase to maintain column life.

OmniPac® PCX-500 Mixed-Mode Column Features:

  • Good for the simultaneous separation of neutral and cationic species
  • Acid and base compatible, pH 0–14
  • 100% solvent compatible
  • Not as effective as the CS12A for inorganic cations

Column Details:

  • Length: 250 mm
  • ID: 4.0 mm