Neo 5.5 - sCMOS Camera

A promising development for scientific imaging is the improvement of complementary metal oxide semiconductor (CMOS) sensors. These devices have progressed to a point that makes them suitable for biological microscopy. Recently, a series of review articles and technical “white paper” reports discussing the merits of scientific CMOS (sCMOS) camera technology for biological microscopy have appeared in various periodicals, each written by a representative of the several reputable scientific camera manufacture companies. It has been suggested that the latest generation sCMOS cameras have the potential to out-compete or even supplant electron multiplication CCD (EMCCD) cameras, which to-date have been established as the leading imaging detector technology for low-light biological microscopy applications. This application note provides an overview of the cited benefits of sCMOS cameras over existing camera technologies.

Imaging fluorescence in moving cells is fundamentally challenging because the exposure time is constrained by motion-blur, which limits the available signal. A team at Harvard University has developed a method that enables fluorescence imaging of fluorescently labeled cells traveling at high linear velocities in fluids. This method uses the Neo 5.5 and the Zyla 5.5 cameras from Andor, which offer a large field of view and high resolution without compromising read noise or frame rate.

Particle Imaging Velocimetry is an optical method of flow visualization used in research and industry to obtain velocity measurements and related properties in fluids. This application note details how to integrate the Andor Scientific CMOS (sCMOS) family of cameras, Neo and Zyla, into a particle imaging velocimetry setup.

This case study describes a magnetophoresis method, using the Andor Neo sCMOS camera, to study how different magnetic nanoparticles are taken up by a variety of cells including cancer cells and stem cells.

Since the launch of imaging cameras that are based on a sCMOS sensor there has been much speculation about whether or not sCMOS will replace for interline CCD and EMCCD cameras. This note provides an analysis of how these sensitive imaging technologies compare.

Andor's microscopy solutions provide best-in-class performance within a modular architecture and can cater for a wide number of application fields in the world of cell biology. This video shows examples of a number of applications for which Andor’s range of cell biology toolkits can be used.

Watch this interview with Christian Felsheim, Andor Technology, to learn more about the new product launched at the show. The Zyla sCMOS camera is designed to offer high speed, high sensitivity imaging performance in a remarkably light and compact, TE cooled design. The Neo sCMOS camera is able to simultaneously offer ultra-low noise, rapid frame rates, wide dynamic range, high resolution and a large field of view, including snapshot shutter ‘freeze frame’ capture capability. Interview filmed by SelectScience at Analytica 2012.

Learn about the launch of the new Andor Scientific CMOS camera in this video interview. Gary Hancock, Andor Scientific, highlights the unique features and benefits of the new camera including its speed, cooling capabilities, and read out noise of 1 electron. Scientists now have the opportunity to see a larger, more detailed image in their field of view. The technology is designed to enhance image focus for biologists examining samples with more detail than previously possible. Filmed by SelectScience at ASCB 2011.

Watch this interview to find out more about the new Neo Camera for biological imaging from Andor Technology. Based on sCMOS technology, the camera provides a combination of speed, sensitivity, high resolution and large field of view. Ultra low read noise is also achieved alongside fast frame rates. ASCB 2010 interview.

Innovative microfabrication and class-leading sCMOS camera lead to a new microscopy method